复发性流产患者蜕膜和绒毛组织中TNF-α、水通道蛋白1的表达变化及意义
发布时间：2019-07-08 11:37
【摘要】：目的观察复发性流产(RSA)患者蜕膜和绒毛组织中TNF-α、水通道蛋白(AQP)1的表达变化,并探讨其意义。方法采用免疫组化法对60例RSA患者(RSA组)和20例正常早孕人工流产者(对照组)蜕膜及绒毛组织中的TNF-α、AQP1进行检测。结果 RSA组、对照组蜕膜组织TNF-α阳性表达率分别为80%(48/60)、60.0%(12/20),AQP1阳性表达率分别为42%(25/60)、55%(11/20),两组两指标相比,P均0.05。RSA组、对照组绒毛组织中TNF-α阳性表达率分别为75%(45/60)、15%(3/20),AQP1阳性表达率分别为20%(12/60)、25%(15/20),两组两指标相比,P均0.05。RSA组绒毛组织中TNF-α与AQP1的表达呈负相关(r=-0.385、P0.05)。结论 RSA患者绒毛组织中TNF-α表达增加、AQP1表达减少,而且两者的表达水平呈负相关关系;TNF-α、AQP1可能共同参与了RSA的发病过程。
[Abstract]:Objective to observe the expression of TNF- 伪 and aquaporin (AQP) 1 in decidua and villi of patients with recurrent abortion (RSA) and to explore their significance. Methods Immunohistochemical method was used to detect TNF- 伪 and AQP1 in decidua and villi of 60 patients with RSA (RSA group) and 20 patients with normal early pregnancy induced abortion (control group). Results in RSA group, the positive expression rates of TNF- 伪 in decidua of control group were 80% (48 鈮，
本文编号：2511556
[Abstract]:Objective to observe the expression of TNF- 伪 and aquaporin (AQP) 1 in decidua and villi of patients with recurrent abortion (RSA) and to explore their significance. Methods Immunohistochemical method was used to detect TNF- 伪 and AQP1 in decidua and villi of 60 patients with RSA (RSA group) and 20 patients with normal early pregnancy induced abortion (control group). Results in RSA group, the positive expression rates of TNF- 伪 in decidua of control group were 80% (48 鈮，
本文编号：2511556
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