PCOS患者卵泡液维生素D水平与IVF周期结局相关性分析
发布时间：2019-07-09 18:49
【摘要】：目的探讨多囊卵巢综合征(Polycystic Ovary Syndrome,PCOS)患者卵泡液中维生素D水平变化与体外受精-胚胎移植(In Vitro Fertilization and Embryo Transfer,IVF-ET)周期临床妊娠的相关性。方法选取首次接受IVF-ET治疗的PCOS患者61例,根据治疗结局分为临床妊娠组(A组)和临床未妊娠组(B组),采用ELISA法测定血浆及卵泡液25(OH)D水平,分析卵泡液中25(OH)D水平与IVF临床妊娠是否相关。结果血浆25(OH)D与卵泡液25(OH)D水平直线相关(R方为0.914,调整R方为0.913;P0.05);A组与B组相比,血浆25(OH)D分别为(31.9±4.67)ng/ml和(21.11±3.31)ng/ml、卵泡液25(OH)D分别为(32.02±3.68)ng/ml和(19.76±3.37)ng/ml,差异均有统计学意义(P0.05);卵泡液25(OH)D水平与临床妊娠密切相关[OR值(95%CI)为1.60(1.3~2.24);P0.05]。结论 PCOS患者卵泡液25(OH)D水平可反映体内25(OH)D水平,卵泡液25(OH)D水平可作为监测PCOS患者IVF成功的独立因素。
[Abstract]:Objective to investigate the relationship between vitamin D level in follicular fluid and clinical pregnancy in vitro fertilization and embryo transfer (In Vitro Fertilization and Embryo Transfer,IVF-ET) cycle in patients with polycystic ovary syndrome (Polycystic Ovary Syndrome,PCOS). Methods 61 patients with PCOS treated with IVF-ET for the first time were divided into clinical pregnancy group (group A) and clinical non-pregnant group (group B) according to the outcome of treatment. The levels of 25 (OH) D in plasma and follicular fluid were measured by ELISA method. The correlation between 25 (OH) D level in follicular fluid and clinical pregnancy of IVF was analyzed. Results there was a linear correlation between plasma 25 (OH) D and follicular fluid 25 (OH) D level (R side was 0.914, adjusted R side was 0.913 脳 0.05). Compared with group B, plasma 25 (OH) D was (31.9 卤4.67) ng/ml and (21.11 卤3.31) ng/ml, respectively, and the levels of 25 (OH) D in follicular fluid were (32.02 卤3.68) ng/ml and (19.76 卤3.37) ng/ml, respectively (P 0.05), and the level of 25 (OH) D in follicular fluid was closely related to clinical pregnancy [OR = 1.60 (1.3 鈮，
本文编号：2512364
[Abstract]:Objective to investigate the relationship between vitamin D level in follicular fluid and clinical pregnancy in vitro fertilization and embryo transfer (In Vitro Fertilization and Embryo Transfer,IVF-ET) cycle in patients with polycystic ovary syndrome (Polycystic Ovary Syndrome,PCOS). Methods 61 patients with PCOS treated with IVF-ET for the first time were divided into clinical pregnancy group (group A) and clinical non-pregnant group (group B) according to the outcome of treatment. The levels of 25 (OH) D in plasma and follicular fluid were measured by ELISA method. The correlation between 25 (OH) D level in follicular fluid and clinical pregnancy of IVF was analyzed. Results there was a linear correlation between plasma 25 (OH) D and follicular fluid 25 (OH) D level (R side was 0.914, adjusted R side was 0.913 脳 0.05). Compared with group B, plasma 25 (OH) D was (31.9 卤4.67) ng/ml and (21.11 卤3.31) ng/ml, respectively, and the levels of 25 (OH) D in follicular fluid were (32.02 卤3.68) ng/ml and (19.76 卤3.37) ng/ml, respectively (P 0.05), and the level of 25 (OH) D in follicular fluid was closely related to clinical pregnancy [OR = 1.60 (1.3 鈮，
本文编号：2512364
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