不孕妇女生殖道感染病原学研究

发布时间：2019-07-26 20:14

【摘要】：目的探究不孕妇女生殖道感染病原体分布,为合理运用抗菌药物提供依据。方法选取2012年1月-2014年12月医院收治的100例不孕妇女作为观察组,并选取同期100名健康妊娠妇女作为对照组,对所有研究对象的阴道和宫颈分泌物进行有关病原体的实验室检查。结果观察组中检出细菌16株、支原体属48株,检出率分别为16.0%、48.0%,对照组中分别检出13、28株,检出率为13.0%、28.0%,差异有统计学意义(P0.05);生殖道清洁度Ⅲ~Ⅳ度分布率观察组与对照组比较,差异无统计学意义,观察组pH4.5分布率为51.0%,高于对照组的37.0%,差异有统计学意义(P0.05);解脲脲支原体对米诺环素和多西环素的敏感率90.0%,对喹诺酮类药物敏感率40.0%。结论造成妇女不孕的原因主要为支原体属感染和细菌性阴道病病原菌,应当加强对女性生殖道的检测,并合理使用抗菌药物。
[Abstract]:Objective to investigate the distribution of pathogens in infertile women with reproductive tract infection and to provide evidence for rational use of antibiotics. Methods from January 2012 to December 2014, 100 infertile women were selected as the observation group, and 100 healthy pregnant women were selected as the control group. The vaginal and cervical secretions of all the subjects were examined in the laboratory. Results 16 strains of bacteria and 48 strains of Mycoplasma were detected in the observation group (16.0%) and the control group (48.0%). In the control group, the detection rate was 13.0% and 28.0%, the difference was statistically significant (P 0.05). There was no significant difference in the distribution rate of reproductive tract cleanliness between the observation group and the control group. The distribution rate of pH4.5 in the observation group was 51.0%, which was significantly higher than that in the control group (37.0%) (P 0.05). The sensitivity rate of Ureaplasma Urealyticum to minocycline and doxycycline was 90.0% and 40.0% to quinolones. Conclusion the main causes of infertile women are mycoplasma infection and bacterial vaginosis pathogens. The detection of female reproductive tract should be strengthened and antibiotics should be used reasonably.
【作者单位】：浙江省宁海县妇幼保健院妇产科;杭州市余杭区妇幼保健院妇科;
【基金】：国家自然科学基金资助项目(81101250)
【分类号】：R711.6

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