保妇康栓治疗人乳头瘤病毒感染的临床观察

发布时间：2019-07-30 22:10

【摘要】：目的:研究保妇康栓治疗宫颈人乳头瘤病毒(HPV)感染的临床疗效。方法:采用多中心随机对照研究,选择6家医院的宫颈HPV感染者共243例,随机分为保妇康栓组161例,空白对照组82例,分析比较两组疗效;选择感染不同HPV亚型的患者,分为保妇康栓组和空白对照组,比较两组的疗效。结果:治疗HPV感染4个月、8个月后,保妇康栓组的总有效率优于空白对照组,两组总有效率比较差异有统计学意义(P0.01);保妇康栓治疗高危型HPV68、52、53、16、18的转阴率分别为91.67%、84.85%、83.33%、70.73%、70.00%,高于空白对照组,但差异无统计学意义(P0.05);HPV52和HPV68感染的患者保妇康栓组治疗后转阴率(84.85%、91.67%)与空白对照组(27.27%、42.86%)比较,差异有统计学意义(P0.05)。结论:保妇康栓能有效清除HPV病毒,使HPV感染患者转阴,值得临床推广。
[Abstract]:Objective: to study the clinical effect of Baofukang suppository in the treatment of cervical human papillomavirus (HPV) infection. Methods: a total of 24 cases of cervical HPV infection in 6 hospitals were randomly divided into Baofukang suppository group (n = 161) and blank control group (n = 82). The curative effects of the two groups were analyzed and compared, and the patients infected with different HPV subtypes were divided into Baofukang thrombus group and blank control group, and the curative effects of the two groups were compared. Results: after 4 months and 8 months of treatment of HPV infection, the total effective rate of Baofukang suppository group was better than that of blank control group, and there was significant difference between the two groups (P 0.01). The negative conversion rate of high risk HPV68,52,53,16,18 was 41.67%, 84.85%, 70.73%, 70.00%, higher than that of blank control group, but the difference was not statistically significant (P 0.05). The negative conversion rate of patients with HPV52 and HPV68 infection after treatment (84.85%, 41.67%) was significantly different from that of the blank control group (27.27%, 42.86%) (P 0.05). Conclusion: Baofukang suppository can effectively eliminate HPV virus and turn negative in patients with HPV infection, which is worthy of clinical promotion.
【作者单位】：北京大学第一医院;广东省深圳市人民医院;上海交通大学附属仁济医院;卫生部北京医院;华中科技大学同济医学院附属同济医院;浙江大学医学院附属妇产科医院;
【分类号】：R737.33

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