不同发育天数囊胚冻融移植后妊娠结局分析

发布时间：2019-08-12 11:40

【摘要】：目的比较不同发育天数冻融囊胚移植后的妊娠结局。方法回顾性分析1 176例行冻融囊胚移植患者的临床资料,其中植入前遗传学诊断(preimplantation genetic diagnosis,PGD)周期135例,比较第5日单囊胚移植(single embryo transfer,SET)组、双囊胚移植(double embryo transfer,DET)组与第6日SET组和DET组的妊娠结局。结果同是优质囊胚级别的条件下,第5日DET组的生化妊娠率(56.91%)、临床妊娠率(53.25%)以及多胎妊娠率(1.20%)显著高于其他组(P0.05);第5日DET组与SET组的胚胎着床率无统计学差异(P0.05),但均显著高于第6日DET组和SET组(P0.05);同级别以及PGD周期中第5日和第6日SET组相比较,第5日组的生化妊娠率、胚胎着床率均显著高于第6日组(P0.05)。结论在同是优质囊胚的条件下,第5日SET、DET及经PGD诊断的SET妊娠结局均优于第6日。
[Abstract]:Objective to compare the pregnancy outcomes after freeze-thaw blastocyst transfer in different development days. Methods the clinical data of 1176 patients undergoing freeze-thaw blastocyst transfer were analyzed retrospectively. the pregnancy outcomes of single blastocyst transfer (single embryo transfer,SET group, double blastocyst transfer (double embryo transfer,DET group, SET group and DET group on the 6th day were compared. Results under the same condition of high quality blastocyst grade, the biochemical pregnancy rate (56.91%), clinical pregnancy rate (53.25%) and multiple pregnancy rate (1.20%) in DET group were significantly higher than those in other groups (P 0.05), and there was no significant difference in embryo implantation rate between DET group and SET group on the 5th day (P 0.05), but they were significantly higher than those in DET group and SET group on the 6th day (P 0.05). Compared with SET group on the 5th and 6th day of PGD cycle, the biochemical pregnancy rate and embryo implantation rate in the 5th day group were significantly higher than those in the 6th day group (P 0.05). Conclusion under the condition of high quality blastocyst, the pregnancy outcome of SET diagnosed by PGD and SET,DET on the 5th day is better than that on the 6th day.
【作者单位】：安徽医科大学第一附属医院妇产科生殖医学中心安徽医科大学生殖与遗传安徽省重点实验室安徽省生命资源保存与人工器官工程技术研究中心;
【基金】：安徽省自然科学基金(1608085QH201)~~
【分类号】：R714.8

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