2001～2011年辽宁省急性心肌梗死住院患者他汀使用情况及其影响因素

发布时间：2018-04-03 14:15

本文选题：急性心肌梗死　切入点：他汀治疗　出处：《中国老年学杂志》2017年11期

【摘要】：目的评价2001~2011年辽宁省急性心肌梗死(AMI)住院患者他汀使用情况及其影响因素。方法调查辽宁省7家协作医院2001、2006和2011 3个特定年份研究病历,以提取临床信息。结果 7家医院共计1 284例适宜他汀治疗的AMI患者病历纳入研究。AMI患者院内他汀的使用率从2001年的43.18%增加到2006年的93.44%和2011年的96.22%(P0.000 1)。不同低密度脂蛋白胆固醇(LDL-C)水平患者他汀使用率均逐年增加(均P0.05)。未检测LDL-C患者他汀使用率显著低于LDL-C检测的患者(P0.000 1)。院内强化他汀的使用率由2001年的1.75%增加到2006年的25.96%和2011年的57.99%(P0.000 1)。多因素模型中,高脂血症患者更容易接受他汀治疗(OR=1.53,95%CI 1.09~2.13,P=0.013)。接受经皮冠状动脉介入(PCI)患者较非PCI患者更容易接受他汀治疗(OR=2.70,95%CI 1.99~3.66,P0.001)。心源性休克患者他汀治疗率明显降低(OR=0.43,95%CI 0.20~0.93,P=0.033)。结论 2001~2011年辽宁省AMI患者他汀类药物应用率明显增加,但2011年仍然有超过40%患者未接受强化他汀治疗。
[Abstract]:Objective to evaluate the use of statins in patients with acute myocardial infarction (AMI) in Liaoning province from 2001 to 2011.Methods the medical records of 7 collaborative hospitals in Liaoning Province were investigated in 2006 and 2011 to extract clinical information.Results in 7 hospitals, 1 284 patients with AMI who were suitable for statins were included in the study. The utilization rate of statins in hospital increased from 43.18% in 2001 to 93.44% in 2006 and 96.22%(P0.000 1 in 2011.The use rate of statins increased year by year in patients with different low density lipoprotein cholesterol (LDL-C) levels (all P 0.05).The use of statins in patients without LDL-C was significantly lower than that in patients with LDL-C.The use of statin in hospital increased from 1.75% in 2001 to 25.96% in 2006 and 57.99%(P0.000 1 in 2011.In multivariate model, patients with hyperlipidemia were more likely to receive statin therapy.Patients undergoing percutaneous coronary intervention (PCI) were more likely to receive statins than those without PCI.The treatment rate of statins in patients with cardiogenic shock was significantly lower than that in patients with cardiac shock.Conclusion the application rate of statins in AMI patients in Liaoning Province increased significantly from 2001 to 2011, but more than 40% of the patients still did not receive intensive statins in 2011.
【作者单位】：郑州大学附属南阳医院南阳市中心医院心内科;
【基金】：国家科技支撑计划项目(No.2013BAI09B01) 卫生公益性行业科研专项(No.201202025)
【分类号】：R542.22

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