伊伐布雷定对急性心肌梗死兔血清中低氧诱导因子-1α和VEGF表达的影响

发布时间：2018-04-04 00:02

  本文选题：心肌梗死　切入点：伊伐布雷定　出处：《青岛大学》2013年硕士论文

【摘要】：目的：探讨伊伐布雷定对急性心肌梗死模型兔血清中低氧诱导因子-1α(HIF-1a)和血管内皮生长因子(VEGF)表达的影响。 方法：2]只新西兰大白兔随机分为假手术组(S)、心肌梗死组(M)、富马酸比索洛尔治疗组(M+B)、伊伐布雷定治疗组(M+I),其中M+B组自心肌梗死模型当天起以富马酸比索洛尔1.25mg每天1次,服药1周后再以2.5mg每天1次继续服药2周,M+I组以伊伐布雷定17mg/(kg·d)服药3周,对各组兔分别于术前24h、术后24h、术后3d、术后1周、术后2周、术后3周,6个时间点自耳缘静脉抽取静脉血,采用Elisa法检测血清中HIF-1a和VEGF水平。采用心电图机记录并分析各组兔术前及术后3周的心率变化。 结果：3组心肌梗死兔基础心率比较无统计学差异；术后3周与M组相比,M+B和M+I两组心率明显减慢(F=49.61,q=7.54，，P0.05),而M+B和M+I两组相比心率减慢程度无明显差异(P0.05); M、M+B、M+I组不同时间点血清中HIF-1a和VEGF水平与S组相比均明显升高,差异有显著性(F=8.22-11.88, q=4.32-6.73, P0.05), M+B、M+I两组较M组明显降低(F=5.23-12.11, q=3.97-8.32, P0.05), M+B、M+I两组比较差异无显著性(P0.05)；各组兔血清中HIF-1a与VEGF水平呈正相关性(r=0.732,P0.01)。 结论：伊伐布雷定在减慢心率的同时,可降低心肌梗死后血清中HIF-1a和VEGF水平,其疗效与比索洛尔无明显差异。
[Abstract]:Aim: to investigate the effects of ivalburetine on the expression of hypoxia inducible factor 1 伪 (HIF-1a) and vascular endothelial growth factor (VEGF) in serum of rabbits with acute myocardial infarction (AMI).Methods Twenty two New Zealand white rabbits were randomly divided into three groups: sham-operated group, myocardial infarction group, bisoprolol fumarate group, and ivalburetine treatment group. The M B group was treated with 1.25mg once a day since the myocardial infarction model.After 1 week of administration, 2.5mg was given once a day for 2 weeks. The rabbits in the MI group were treated with 17mg/(kg d for 3 weeks. The rabbits in each group were treated at 24 hours before operation, 24 hours after operation, 3 days after operation, 1 week after operation and 2 weeks after operation, respectively.At 3 weeks after operation, venous blood was extracted from the auricular vein at 6 time points and the levels of HIF-1a and VEGF in serum were detected by Elisa method.The changes of heart rate before and 3 weeks after operation were recorded and analyzed by electrocardiograph.Results there was no significant difference in basal heart rate among the three groups.鏈�鍚�3鍛ㄤ笌M缁勭浉姣

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