心绞痛和急性心梗患者血清HMGB1水平与hs-CRP的相关性研究
发布时间：2018-04-04 00:31
本文选题：动脉粥样硬化 切入点：冠心病 出处：《宁夏医科大学》2013年硕士论文
【摘要】：目的通过对健康人群、心绞痛患者以及急性心肌梗死患者中血清高迁移率族蛋白B1（HMGB1）及超敏C-反应蛋白（hs-CRP）水平的测定，研究HMGB1和冠状动脉病变程度的关系，以及HMGB1在反映冠脉狭窄程度上与hs-CRP的相关性，以探讨HMGB1在CHD诊断和治疗中的重要价值。 方法选取上海市浦东新区公利医院心内科2011年12月至2012年10月冠脉造影明确冠心病患者281例（CHD组）,其中心绞痛159例,心肌梗死122例,以及健康人群180例（对照组）作为研究对象。用酶联免疫吸附法（ELISA）方法检测研究对象空腹血清HMGB1和hs-CRP水平。 结果急性心肌梗死（AMI）病人血清HMGB1和hs-CRP水平显著高于心绞痛（AP）和对照组（P㩳0.01）；心绞痛病人血清HMGB1和hs-CRP水平显著高于对照组（P㩳0.01）。CHD各组病人血清HMGB1和hs-CRP水平均呈正相关（r=0.162和r=0.326，P0.05）。 结论血清HMGB1和hs-CRP浓度的变化认为血清AMI和AP具有明确的诊断价值，HMGB1浓度同hs-CRP成为动脉粥样硬化性心脏病的预测因子。
[Abstract]:Objective to study the relationship between HMGB1 and severity of coronary artery disease by measuring the levels of serum high mobility group protein B1HMGB1 and high sensitive C-reactive protein hs-CRP in healthy people, patients with angina pectoris and patients with acute myocardial infarction.And the correlation between HMGB1 and hs-CRP in reflecting the degree of coronary stenosis, so as to explore the important value of HMGB1 in the diagnosis and treatment of CHD.Methods 281 patients with coronary heart disease confirmed by coronary angiography from December 2011 to October 2012, including 159 patients with angina pectoris and 122 patients with myocardial infarction, were selected from Department of Cardiology, Gongli Hospital, Pudong New District, Shanghai.And 180 healthy people (control group) as the study object.The fasting serum HMGB1 and hs-CRP levels were detected by enzyme linked immunosorbent assay (Elisa).缁撴灉鎬ユ，
本文编号：1707579
本文链接：https://www.wllwen.com/yixuelunwen/jjyx/1707579.html
最近更新
教材专著
