早期康复训练对急性脑梗死偏瘫患者的治疗效果及机制探讨

发布时间：2018-06-08 15:07

本文选题：脑梗死 + 偏瘫　；参考：《重庆医学》2017年21期

【摘要】：目的观察早期康复训练对急性脑梗死偏瘫患者的治疗效果,并探讨其可能的机制。方法选取2013年1月至2016年6月该院收治的急性脑梗死偏瘫患者100例,将其分为康复训练组和对照组,各50例。对照组给予常规药物治疗,康复训练组在常规药物治疗的基础上给予早期康复训练,使用功能独立性测评(FIM)、Fugl-Meyer评分法(FMA)、改良Barthel指数(MBI)评估治疗效果;采用酶联免疫吸附双抗体夹心法测定血浆基质细胞衍生因子-1α(SDF-1α)水平,流式细胞术测定外周血CD34~+KDR~+水平。结果治疗前两组FIM总分、FIM运动功能评分、FIM认知功能评分、FMA评分、MBI评分、SDF-1α及CD34~+KDR~+水平比较,差异均无统计学意义(P0.05)。治疗后,康复训练组FIM总分、FIM运动功能评分、FMA评分、MBI评分、SDF-1α及CD34~+KDR~+水平均高于对照组,差异均有统计学意义(P0.05)。结论早期康复训练对急性脑梗死偏瘫患者的治疗效果显著,其机制可能与早期康复训练能够促进外周血SDF-1α和CD34~+KDR~+表达有关。
[Abstract]:Objective to observe the effect of early rehabilitation training on patients with acute cerebral infarction hemiplegia and explore its possible mechanism. Methods 100 patients with acute cerebral infarction hemiplegia treated in our hospital from January 2013 to June 2016 were divided into rehabilitation training group and control group with 50 cases each. The control group was given routine drug therapy, the rehabilitation training group was given early rehabilitation training on the basis of routine drug therapy, and the functional independence test was used to evaluate the effect of treatment by FIMM Fugl-Meyer score and modified Barthel Index (MBI). The plasma levels of stromal cell derived factor-1 伪 (SDF-1 伪) and peripheral blood CD34 ~ KDR- 伪 were measured by enzyme-linked immunosorbent assay (Elisa) and flow cytometry (FCM) respectively. Results before treatment, there was no significant difference between the two groups in FIM total score and FIM motor function score, FIM cognitive function score, FMA score, MBI score, SDF-1 伪 and CD34 ~ KDR~ level. After treatment, the FIM total score and FIM motor function score, FMA score, MBI score, SDF-1 伪 and CD34 ~ KDR~ in the rehabilitation training group were higher than those in the control group, and the difference was statistically significant (P 0.05). Conclusion the effect of early rehabilitation training on patients with acute cerebral infarction hemiplegia is remarkable, and the mechanism may be related to the early rehabilitation training can promote the expression of SDF-1 伪 and CD34 ~ KDR~ in peripheral blood.
【作者单位】：浙江省临海市第二人民医院神经内科;
【分类号】：R743.3

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