颅脑损伤患者术后血清中细胞因子与体液免疫变化的临床意义

发布时间：2018-06-08 16:02

本文选题：颅脑损伤 + 肿瘤坏死因子α　；参考：《重庆医学》2016年05期

【摘要】：目的探讨颅脑损伤患者术后血清肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、C反应蛋白(CRP)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、补体C3(C3)水平的动态变化及其临床意义。方法选取北京潞河医院收治的颅脑损伤术后患者100例,分为感染组和非感染组,各50例。对患者均进行血清TNF-α、IL-6、CRP、IgG、IgM、C3水平的检测,并进行术后第1、3、7天的动态观察。结果感染组术后的第1、3天TNF-α、IL-6、CRP、IgG、IgM、C3水平高于非感染组(P0.05),在术后第7天仅有IgG恢复至非感染组水平(P0.05)。感染组TNF-α、IL-6、CRP水平在术后第1、3天呈现增高趋势,第7天呈下降趋势,非感染组无变化趋势;IgM、IgG、C3水平在各组间均无随时间变化的趋势。感染组IL-6水平与格拉斯哥昏迷评分(GCS)分型相关,随病情加重而显著增高(P0.05)。结论 TNF-α、IL-6、CRP、IgG、IgM、C3水平可能在颅脑损伤术后感染的发生中有重要作用,对术后感染的早期诊断、病情严重程度的判断都有重要的辅助诊断价值。
[Abstract]:Objective to investigate the dynamic changes and clinical significance of serum tumor necrosis factor- 伪 (TNF- 伪), interleukin-6 (IL-6) -C-reactive protein (CRP), immunoglobulin G (IGG), immunoglobulin (IgM), and complement C _ 3 (C _ 3) in patients with craniocerebral injury after craniocerebral injury. Methods 100 patients with craniocerebral injury treated in Luhe Hospital were divided into infection group and non-infection group. The serum levels of TNF- 伪 and IL-6 / CRPU IgM3 were measured in all patients, and the dynamic observation was made on the 1st day and 7th day after operation. Results on the 1st day after operation, the level of TNF- 伪 IL-6 in the infected group was higher than that in the non-infected group (P 0.05), and only IgG recovered to the level of P0.05 in the non-infection group on the 7th day after operation. The level of TNF- 伪 IL-6 CRP increased on the 1st day after operation and decreased on the 7th day in the infected group. The level of IL-6 in the infected group was correlated with Glasgow coma score (GCSS) classification, and increased significantly with the severity of the disease (P 0.05). Conclusion the level of TNF- 伪 IL-6 / CRPG _ 3 may play an important role in the occurrence of postoperative infection after craniocerebral injury. It has important value in the early diagnosis of postoperative infection and the judgement of severity of the disease.
【作者单位】：首都医科大学附属北京潞河医院;中国中医科学院眼科医院检验科;
【基金】：国家高技术研究发展计划(863计划)资助项目(2011AA02A111)
【分类号】：R651.15

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