盐酸法舒地尔注射液对急性脑梗死患者血清血管内皮生长因子、血管生长素-1浓度的影响

发布时间：2018-06-21 14:24

本文选题：法舒地尔 + 急性脑梗死　；参考：《中国老年学杂志》2017年11期

【摘要】：目的观察盐酸法舒地尔注射液对急性脑梗死(ACI)患者血清血管内皮生长因子(VEGF)和血管生成素(Ang)-1浓度的影响。方法采用前瞻性随机、对照试验方案,连续选取82例住院治疗的ACI患者,分为治疗组44例,对照组38例。对照组采用控制血压、抗血小板聚集、调脂等常规治疗,治疗组在常规治疗基础上给予盐酸法舒地尔注射液30 mg加入0.9%生理盐水250 ml静脉滴注,每日2次,共治疗14 d。所有入选患者均于治疗前、治疗后第3天、第7天、第14天清晨取肘静脉血,采取双抗体夹心联酶免疫吸附(ELISA)法测定血清VEGF、Ang-1浓度。结果治疗后两组美国国立卫生研究院脑卒中量表(NIHSS)评分较治疗前均有明显改善,但治疗组NIHSS评分改善较对照组更为显著(P0.01)。治疗第3天、第14天时治疗组与对照组比较VEGF变化无统计学差异(P0.05),至第7天时两组比较有显著差异(P0.01)。治疗后第3天、第7天时治疗组与对照组比较Ang-1变化无统计学意义(P0.05),至第14天时两组比较有统计学差异(P0.05)。治疗组、对照组在治疗后第7天、第14天与各组治疗前相比,VEGF变化有统计学意义(P0.05),血清VEGF浓度在治疗后第7天达到高峰。治疗组、对照组在治疗后第14天分别与各组治疗前相比,Ang-1变化有统计学差异(P0.05),血清Ang-1浓度在治疗后第14天仍呈上升趋势。结论法舒地尔可促进脑缺血后VEGF、Ang-1的高表达,促进血管新生,改善神经功能缺损。
[Abstract]:Objective to observe the effect of fasudil hydrochloride injection on serum vascular endothelial growth factor (VEGF) and angiopoietin (Ang)-1 in patients with acute cerebral infarction (ACI). Methods 82 consecutive patients with ACI were randomly divided into treatment group (n = 44) and control group (n = 38). The control group was treated with conventional therapy such as controlling blood pressure, anti-platelet aggregation and regulating lipid. On the basis of routine treatment, the treatment group was given 30 mg fasudil hydrochloride and 0.9% normal saline 250ml intravenously, twice a day, for 14 days. All the patients were enrolled before treatment, 3 days, 7 days and 14 days after treatment. The serum levels of VEGF Ang-1 were measured by double antibody sandwich enzyme immunosorbent assay (Elisa). Results after treatment, the NIHSS scores of the two groups were significantly improved compared with those before treatment, but the improvement of NIHSS score in the treatment group was more significant than that in the control group (P 0.01). There was no significant difference in VEGF between the treatment group and the control group on the 3rd and 14th day after treatment, but there was significant difference between the two groups on the 7th day. There was no significant difference in Ang-1 between the treatment group and the control group on the 3rd and 7th day after treatment, but there was significant difference between the two groups on the 14th day. In the treatment group, the changes of VEGF in the control group were significantly different from those before treatment on the 7th and 14th day after treatment, and the concentration of serum VEGF reached its peak on the 7th day after treatment. In the treatment group, the changes of Ang-1 in the control group were significantly different from those before treatment on the 14th day after treatment. The serum Ang-1 level was still rising on the 14th day after treatment. Conclusion fasudil can promote the high expression of VEGF Ang-1, promote angiogenesis and improve neural function defect after cerebral ischemia.
【作者单位】：河南大学淮河医院神经内科;河南中医学院第一附属医院;广东省中医院内六科;
【基金】：开封市2014年社会发展科技攻关计划(No.1403004)
【分类号】：R743.3

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