急性重症脑梗死患者S100β蛋白、CRP与神经功能缺损程度及预后的相关性研究

发布时间：2018-06-24 17:27

本文选题：S100β蛋白 + C反应蛋白　；参考：《新乡医学院》2017年硕士论文

【摘要】：背景:国内外研究显示一些生化标志物如S100β蛋白(S100βCalcium-binding protein)、C反应蛋白(C-reactive protein,CRP)对急性脑梗死的诊断、病情严重程度及预后的判断有积极的帮助,但缺乏对急性重症脑梗死患者的针对性研究;探究上述指标对重症脑梗死患者病情严重性及短期病情演变的相关性,将对指导患者的治疗方案、了解患者预后、制定改善预后的预防措施起到重要作用。目的:探讨急性期血清S100β蛋白、CRP浓度与急性重症脑梗死患者入院时神经功能缺损程度及预后的关系。方法:(1)收集急性重症脑梗死患者40例,入院当天采集静脉血,ELISA法测定血清S100β蛋白及血清CRP浓度,采用美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)对入选者神经功能缺损程度进行评估,并收集同期轻型急性脑梗死患者37例;(2)分别在入院后30天、90天对重症脑梗死患者进行面对面或电话随访,应用改良Ranking量表(modified Ranking Scale,mRS)对患者神经功能恢复情况进行评估,探讨急性期血清S100β蛋白、CRP浓度与急性重症脑梗死患者预后的关系;(3)根据两次随访评分变化情况将患者病情变化趋势分为死亡、恶化、稳定及改善,探讨急性期血清S100β蛋白、CRP浓度与急性重症脑梗死患者90天内病情变化之间的关系。结果:(1)急性期血清CRP水平与患者神经功能缺损程度呈正相关性,血清S100β蛋白水平与患者神经功能缺损程度之间无相关性,且血清S100β蛋白水平与CRP水平之间无相关性;(2)急性期血清CRP水平分别与患者30天、90天预后呈正相关性,血清S100β蛋白水平与患者30天、90天预后之间无相关性;(3)急性重症脑梗死患者血清CRP浓度与90天内病情变化情况呈负相关性。结论:(1)急性期高血清CRP水平与急性重症脑梗死患者神经功能缺损严重程度及90天内不良预后呈正相关;(2)血清S100β蛋白与重症脑梗死患者神经功能缺损严重程度及预后无明显相关性。
[Abstract]:Background: studies at home and abroad show that some biochemical markers, such as S100 尾 Calcium-binding protein (S100 尾 -Calcium-binding protein) C-reactive protein (CRP), are helpful in the diagnosis, severity and prognosis of acute cerebral infarction. However, there is a lack of targeted research on the patients with acute severe cerebral infarction, to explore the correlation between the above indexes and the severity of the disease and the short-term development of the patients, which will guide the treatment plan of the patients and understand the prognosis of the patients. Making preventive measures to improve prognosis plays an important role. Objective: to investigate the relationship between the concentration of serum S100 尾 protein and CRP in patients with acute severe cerebral infarction. Methods: (1) 40 patients with acute severe cerebral infarction were collected. The serum S100 尾 protein and serum CRP were measured by Elisa on the day of admission. The National Institute of Health stroke scale (NIHSS) was used to evaluate the degree of neurological impairment in the selected patients. 37 patients with mild acute cerebral infarction in the same period were collected. (2) face to face or telephone follow-up of patients with severe cerebral infarction were carried out 30 days after admission and 90 days after admission, and the neurological function recovery was evaluated by modified ranking scale (RS). To investigate the relationship between serum S100 尾 protein CRP concentration and prognosis of patients with acute severe cerebral infarction (ACI). (3) according to the changes of two follow-up scores, the patients were divided into death, deterioration, stability and improvement. To investigate the relationship between serum S100 尾 protein and CRP in patients with acute severe cerebral infarction within 90 days. Results: (1) the level of serum CRP was positively correlated with the degree of neurological impairment in patients with acute stage, but there was no correlation between the level of serum S100 尾 protein and the degree of neurological impairment in patients. There was no correlation between serum S100 尾 protein level and CRP level. (2) there was a positive correlation between serum CRP level in acute phase and prognosis of 30 days and 90 days, respectively. There was no correlation between serum S100 尾 protein level and prognosis of 30 days and 90 days. (3) there was a negative correlation between serum CRP concentration and the state of disease within 90 days after acute severe cerebral infarction. Conclusion: (1) the high serum CRP level in acute stage is positively correlated with the severity of neurological deficit and the poor prognosis in 90 days in patients with acute severe cerebral infarction, (2) the level of serum S100 尾 protein is positively correlated with the severity of neurological impairment and preconditioning in patients with severe cerebral infarction. There was no significant correlation after operation.
【学位授予单位】：新乡医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R743.3

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