动态监测创伤脓毒症患者血浆中的HMGB-1和IL-13及IL-17含量的意义

发布时间：2018-06-28 13:06

本文选题：创伤脓毒症高迁移率族蛋白B + 白介素-　；参考：《中华肿瘤防治杂志》2016年S2期

【摘要】：目的动态监测创伤脓毒症及非脓毒症血浆中HMGB-1、IL-13、IL-17的量,初步探究创伤脓毒症发生发展中部分细胞因子的作用,为临床治疗提供依据。方法将江苏大学附属武进医院2013-10-2015-10收治的28例患者及体检中心健康人群为研究对象。分为创伤脓毒症组、创伤非脓毒症组。其中创伤脓毒症组14例、创伤非脓毒症组14例及正常对照组20例。用酶联免疫分析法测其血浆中HMGB-1、IL-13、IL-17的量。结果:HMGB-1、IL-13、IL-17的含量与对照组比较,在创伤脓毒症组及创伤非脓毒症组均明显升高(P0.05);在创伤脓毒症组,与创伤非脓毒症组比较HMGB-1和IL-1的含量明显升高(P0.05),而IL-17含量并没有显著提高,且各组组内各时间点件没有显著差异。结论HMGB-1、IL-17,IL-13含量在创伤脓毒症的病情演变中都起着重要的作用。及时监测HMGB-1、IL-13的变化,可更敏感地判断创伤脓毒症的发生,评估其严重程度,为临床治疗提供依据。
[Abstract]:Objective to investigate the role of some cytokines in the pathogenesis and development of traumatic sepsis by dynamically monitoring the level of IL-13 IL-17 in plasma of traumatic sepsis and non-sepsis, and to provide evidence for clinical treatment. Methods 28 patients admitted to Wujin Hospital of Jiangsu University in 2013-10-2015-10 and healthy people in physical examination Center were studied. The patients were divided into trauma sepsis group and trauma non sepsis group. There were 14 cases of traumatic sepsis group, 14 cases of traumatic non-sepsis group and 20 cases of normal control group. The level of HMGB-1 IL-13 IL-17 in plasma was measured by enzyme-linked immunosorbent assay (Elisa). Results compared with the control group, the content of IL-17 in the 1: HMGB-1 group was significantly higher than that in the control group (P0.05), and in the traumatic sepsis group, the levels of HMGB-1 and IL-1 were significantly higher than those in the traumatic non-septic group (P0.05), but the level of IL-17 was not significantly increased. And there was no significant difference in each time point in each group. Conclusion the level of IL-17 IL-13 plays an important role in the development of traumatic sepsis. Monitoring the changes of HMGB-1 IL-13 in time can more sensitively judge the occurrence of traumatic sepsis, evaluate its severity, and provide evidence for clinical treatment.
【作者单位】：常州市武进人民医院急诊科;
【基金】：江苏大学临床医学科技发展基金(JLY201200-40) 常州市社会发展科技计划(CS20102002)
【分类号】：R459.7

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