急性脑出血的血肿扩大与血清总胆固醇和低密度脂蛋白胆固醇的关系
发布时间：2018-07-30 07:00
【摘要】：目的 研究急性脑出血患者血肿扩大与血清TC，LDL-C水平的关系。 方法 1、根据入选标准和排除标准，纳入2010年12月～2013年01月在我院急诊科就诊并收入神经内科病房住院的脑出血患者共144例； 2、对病例组与对照组所有研究对象进行一般资料统计； 3、所有患者入院后即刻手动血压计人工测量血压，进行NIHSS评分，选择评分1～20分患者作为研究对象； 4、所有患者入院后6h内均经头颅CT证实为幕上出血（包括壳核、脑叶、丘脑出血），并于入院后24h复查头颅CT，按照多田公式测量并计算血肿体积，以第二次CT血肿量比第一次增加33%定义为血肿扩大，其中血肿扩大组72例，男51例，女21例；对照组72例，男52例，女20例。 5、所有血肿扩大组及对照组均在发病6h内生化试管抽取静脉血5ml，送本院检验中心，由全自动生化分析仪利用GOD法检测GLU，CHOD-PAP法检测TC数值，SUR法检测LDL-C数值； 6、对2组临床资料进行比较，对血肿扩大的影响因素进行统计学分析。 结果 1、2组的性别分布、出血部位组成无差异（P＞0.05）； 2、2组NIHSS评分、初始出血量数值无差异（P＞0.05）； 3、血肿扩大组年龄：62.74±10.14岁，SBP：177.06±25.31mmHg，DBP：103.83±14.52mmHg，GLU：8.06±4.94mmol/L，明显高于对照组（P0.05）； 4、血肿扩大组TC：3.78±0.62mmol/L，LDL-C：2.10±0.47mmol/L，明显低于对照组（P0.05）。 5、Logistic回归模型分析筛选出的变量为：LDL-C(OR=0.001,95%CI:0.001-0.024,p0.001)，，TC(OR=0.057,95%CI:0.004-0.863,p=0.0322)，GLU(OR=1.851,95%CI:1.219-2.810,p=0.0038)，SBP(OR=1.120,95%CI:1.021-1.229,p=0.0165)，DBP(OR=1.152,95%CI:1.052-1.262,p=0.0023)。 结论 急性脑出血的血肿扩大影响因素包括TC，LDL-C，GLU，SBP和DBP，其中，LDL-C及TC影响最大，故ICH血肿扩大与血清LDL-C，TC水平呈负关系。
[Abstract]:Objective to study the relationship between hematoma enlargement and serum TCU LDL-C level in patients with acute intracerebral hemorrhage. Methods 1. According to the inclusion criteria and exclusion criteria, 144 patients with intracerebral hemorrhage were enrolled in the emergency department of our hospital from December 2010 to January 2013 and admitted to the department of neurology. 2, the general data of all the subjects in the case group and the control group were statistically analyzed. 3, all the patients were manually measured their blood pressure by manual sphygmomanometer immediately after admission to hospital, and their NIHSS scores were scored. Patients with 1-20 scores were selected as the study subjects. 4, all patients were confirmed as supratentorial hemorrhage (including putamen nucleus, lobes of brain) by cranial CT within 6 hours after admission. Thalamic hemorrhage), and at 24 hours after admission, the volume of hematoma was measured and calculated according to Duotian formula. The hematoma enlargement was defined as hematoma enlargement by 33% in the second CT group, including 72 cases in the hematoma enlargement group, 51 cases in the male and 21 cases in the female. There were 72 cases in control group, 52 cases in male and 20 cases in female. All hematoma enlargement group and control group were collected 5 ml of venous blood in biochemical tube within 6 hours after the onset of the disease, and sent to the laboratory center of our hospital. GOD method was used to detect GLU CHOD-PAP method to detect TC value and sur method to detect LDL-C value. 6, two groups of clinical data were compared, and the influencing factors of hematoma enlargement were analyzed statistically. Results (1) there was no significant difference in sex distribution and bleeding site composition between the two groups (P > 0. 05), but there was no difference in NIHSS score and initial bleeding volume between the two groups (P > 0. 05). 3,琛
本文编号：2154214
[Abstract]:Objective to study the relationship between hematoma enlargement and serum TCU LDL-C level in patients with acute intracerebral hemorrhage. Methods 1. According to the inclusion criteria and exclusion criteria, 144 patients with intracerebral hemorrhage were enrolled in the emergency department of our hospital from December 2010 to January 2013 and admitted to the department of neurology. 2, the general data of all the subjects in the case group and the control group were statistically analyzed. 3, all the patients were manually measured their blood pressure by manual sphygmomanometer immediately after admission to hospital, and their NIHSS scores were scored. Patients with 1-20 scores were selected as the study subjects. 4, all patients were confirmed as supratentorial hemorrhage (including putamen nucleus, lobes of brain) by cranial CT within 6 hours after admission. Thalamic hemorrhage), and at 24 hours after admission, the volume of hematoma was measured and calculated according to Duotian formula. The hematoma enlargement was defined as hematoma enlargement by 33% in the second CT group, including 72 cases in the hematoma enlargement group, 51 cases in the male and 21 cases in the female. There were 72 cases in control group, 52 cases in male and 20 cases in female. All hematoma enlargement group and control group were collected 5 ml of venous blood in biochemical tube within 6 hours after the onset of the disease, and sent to the laboratory center of our hospital. GOD method was used to detect GLU CHOD-PAP method to detect TC value and sur method to detect LDL-C value. 6, two groups of clinical data were compared, and the influencing factors of hematoma enlargement were analyzed statistically. Results (1) there was no significant difference in sex distribution and bleeding site composition between the two groups (P > 0. 05), but there was no difference in NIHSS score and initial bleeding volume between the two groups (P > 0. 05). 3,琛
本文编号：2154214
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