急性脑出血患者血清炎症因子和C-反应蛋白的动态监测及在病情恶化中的预测价值

发布时间：2018-09-11 06:21

【摘要】：目的探讨急性脑出血患者血清炎症因子和C-反应蛋白(CRP)的动态变化及临床意义。方法测定120例健康对照者及120例急性脑出血患者发病24 h内、3、7 d及14d时血清肿瘤坏死因子(TNF)-α、白介素(IL)-1β、IL-6、IL-8、CRP的水平,并分别将这些指标与出血量的大小、病情严重程度进行相关性分析,利用受试者工作特征曲线分析其对急性脑出血病情恶化的临床预测意义。结果急性脑出血患者不同时期内血清TNF-α、IL-1β、IL-6、IL-8、CRP水平均高于对照组(P0.05);血清TNF-α、IL-1β、IL-6、IL-8和CRP水平与患者脑出血量大小、病情严重程度呈正相关性(P0.05);炎症因子和CRP的水平对急性脑出血病情的恶化具有显著的预测价值。结论血清炎症因子和CRP参与了脑出血的病理生理过程,且这些指标对于患者病情具有重要的预测价值。
[Abstract]:Objective to investigate the dynamic changes and clinical significance of serum inflammatory factors and C-reactive protein (CRP) in patients with acute intracerebral hemorrhage. Methods Serum levels of tumor necrosis factor- 伪 (TNF)-伪) and interleukin-1 (IL)-1 尾) interleukin-6 (IL-6) IL-8CRP were measured in 120 healthy controls and 120 patients with acute intracerebral hemorrhage within 24 hours after the onset of ICH, and the levels of TNF- 伪, IL-6 and IL-8 were measured. The correlation analysis of the severity of the disease and the clinical prediction of the deterioration of acute intracerebral hemorrhage (AICH) were carried out by using the operating characteristic curve of the subjects. Results the levels of serum TNF- 伪, IL-1 尾, IL-6, IL-8 and IL-8 in patients with acute intracerebral hemorrhage were higher than those in the control group (P0.05), and the levels of IL-8 and CRP in patients with acute intracerebral hemorrhage were significantly higher than those in the control group (P0.05). The severity of the disease was positively correlated (P0.05); the levels of inflammatory factors and CRP had significant predictive value for the deterioration of acute intracerebral hemorrhage. Conclusion Serum inflammatory factors and CRP are involved in the pathophysiological process of intracerebral hemorrhage.
【作者单位】：安徽医科大学附属省立医院神经内科;
【基金】：国家自然科学基金面上项目(编号:81573807)
【分类号】：R743.34

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