老年急性缺血性脑卒中患者血清中尿酸、总胆红素以及脂蛋白等相关因素的综合性分析
发布时间：2018-12-17 02:10
【摘要】：目的探讨老年急性缺血性脑卒中患者血清中尿酸、总胆红素以及脂蛋白水平与其他因素的变化在急性缺血性脑卒中发生发展中的作用以及相关关系的综合性分析。方法选取在2014年1月-2015年12月首次住院治疗的老年急性缺血性脑卒中患者114例(脑卒中组)。急性期24h空腹抽血测定其急性期尿酸、总胆红素、三酰甘油、血糖、高密度脂蛋白、低密度脂蛋白、载脂蛋白B(ApoB)、载脂蛋白A1(ApoA1)、总胆固醇等水平,与同期健康体检者90例(对照组)进行比较。结果急性缺血性脑卒中组体重指数(BMI)、尿酸、三酰甘油、血糖、低密度脂蛋白、ApoB/ApoA1、总胆固醇、收缩压、舒张压明显高于对照组(P0.01);病例组总胆红素和高密度脂蛋白低于对照组(P0.01);尿酸与BMI、三酰甘油、血糖、低密度脂蛋白、ApoB/ApoA1、舒张压呈显著正相关(P0.01),尿酸与总胆红素和收缩压呈负相关(P0.01);总胆红素与高密度脂蛋白呈正相关(P0.01),与尿酸、三酰甘油、血糖、低密度脂蛋白、ApoB/ApoA1、总胆固醇、收缩压以及舒张压呈负相关(P0.01);低密度脂蛋白与BMI、尿酸、血糖、ApoB/ApoA1、总胆固醇呈正相关(P0.01),与年龄、三酰甘油、高密度脂蛋白呈负相关(P0.01);并且以上结果差异均有统计学意义(P0.05)。结论急性脑卒中患者尿酸、总胆红素以及脂蛋白水平的升高都是急性缺血性脑卒中的危险因素,并且这3个独立的危险因素与其他相关因素协同作用,在老年急性缺血性脑卒中发生发展中起到了非常重要的作用。
[Abstract]:Objective to investigate the role of serum uric acid, total bilirubin, lipoprotein and other factors in the occurrence and development of acute ischemic stroke in elderly patients. Methods 114 elderly patients with acute ischemic stroke (stroke group) who were hospitalized for the first time from January 2014 to December 2015 were selected. The levels of uric acid, total bilirubin, triacylglycerol, blood glucose, high density lipoprotein, low density lipoprotein, apolipoprotein B (ApoB), apolipoprotein A1 (ApoA1), total cholesterol and so on were measured in 24 hours of acute phase. The results were compared with 90 healthy persons (control group) in the same period. Results (BMI), uric acid, triglyceride, blood glucose, low density lipoprotein, total cholesterol of ApoB/ApoA1, systolic blood pressure and diastolic blood pressure in acute ischemic stroke group were significantly higher than those in control group (P0.01). The total bilirubin and high density lipoprotein in the case group were lower than those in the control group (P0.01). Uric acid was positively correlated with BMI, triglyceride, blood glucose, low density lipoprotein, ApoB/ApoA1, diastolic blood pressure (P0.01), uric acid was negatively correlated with total bilirubin and systolic blood pressure (P0.01). Total bilirubin was positively correlated with high density lipoprotein (P0.01), negatively correlated with uric acid, triglyceride, blood glucose, low density lipoprotein, total cholesterol of ApoB/ApoA1, systolic blood pressure and diastolic blood pressure (P0.01). Low density lipoprotein was positively correlated with BMI, uric acid, blood glucose, total cholesterol of ApoB/ApoA1, (P0.01), and negatively correlated with age, triglyceride, and high density lipoprotein (P0.01). And the above results were statistically significant (P0.05). Conclusion the elevated levels of uric acid, total bilirubin and lipoprotein in patients with acute stroke are risk factors for acute ischemic stroke, and these three independent risk factors have synergistic effects with other related factors. It plays a very important role in the occurrence and development of acute ischemic stroke in the elderly.
【作者单位】： 东南大学附属中大医院无锡分院神经内科;
【分类号】：R743.33
，
本文编号：2383463
[Abstract]:Objective to investigate the role of serum uric acid, total bilirubin, lipoprotein and other factors in the occurrence and development of acute ischemic stroke in elderly patients. Methods 114 elderly patients with acute ischemic stroke (stroke group) who were hospitalized for the first time from January 2014 to December 2015 were selected. The levels of uric acid, total bilirubin, triacylglycerol, blood glucose, high density lipoprotein, low density lipoprotein, apolipoprotein B (ApoB), apolipoprotein A1 (ApoA1), total cholesterol and so on were measured in 24 hours of acute phase. The results were compared with 90 healthy persons (control group) in the same period. Results (BMI), uric acid, triglyceride, blood glucose, low density lipoprotein, total cholesterol of ApoB/ApoA1, systolic blood pressure and diastolic blood pressure in acute ischemic stroke group were significantly higher than those in control group (P0.01). The total bilirubin and high density lipoprotein in the case group were lower than those in the control group (P0.01). Uric acid was positively correlated with BMI, triglyceride, blood glucose, low density lipoprotein, ApoB/ApoA1, diastolic blood pressure (P0.01), uric acid was negatively correlated with total bilirubin and systolic blood pressure (P0.01). Total bilirubin was positively correlated with high density lipoprotein (P0.01), negatively correlated with uric acid, triglyceride, blood glucose, low density lipoprotein, total cholesterol of ApoB/ApoA1, systolic blood pressure and diastolic blood pressure (P0.01). Low density lipoprotein was positively correlated with BMI, uric acid, blood glucose, total cholesterol of ApoB/ApoA1, (P0.01), and negatively correlated with age, triglyceride, and high density lipoprotein (P0.01). And the above results were statistically significant (P0.05). Conclusion the elevated levels of uric acid, total bilirubin and lipoprotein in patients with acute stroke are risk factors for acute ischemic stroke, and these three independent risk factors have synergistic effects with other related factors. It plays a very important role in the occurrence and development of acute ischemic stroke in the elderly.
【作者单位】： 东南大学附属中大医院无锡分院神经内科;
【分类号】：R743.33
，
本文编号：2383463
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