BOLD-fMRI对急性脑梗死患者初级运动区激活体积及强度的定量分析

发布时间：2018-12-17 15:46

【摘要】：目的：应用血氧水平依赖功能磁共振成像（BOLD-fMRI）定量分析健康自愿者和急性脑梗死偏瘫患者握拳运动后初级运动区（M1）的激活体积与激活强度，，探讨BOLD-fMRI正常人及急性脑梗死偏瘫患者中的应用价值。方法：对20名健康志愿者（正常组）及16名急性脑梗死偏瘫患者（偏瘫组）双手分别行握拳运动BOLD-fMRI检查，应用统计参数图（SPM5）对功能图像进行处理分析，观察受试者全脑激活情况，并用xjView8软件得到全脑最大信号强度的MNI坐标及解剖位置分布。同时选取M1区为感兴趣区（ROI），使用SPSS19.0对M1区激活体积、激活强度进行定量分析。结果：2名正常组及3名偏瘫组受试者因头动校正结果提示头动幅度控制不理想，受试者数据排除。除2例偏瘫组受试者患手握拳全脑未见激活外，正常组及偏瘫组受试者单手握拳运动全脑均可见散在激活，且均以对侧M1区激活明显。正常组双手握拳运动对侧M1区激活体积及激活强度差异均无统计学意义（P0.05）；偏瘫组健手握拳与患手握拳对侧M1区激活体积及激活强度差异均有统计学意义（P0.05）；偏瘫组健侧手握拳与正常组同侧手握拳运动所致对侧M1区激活体积及激活强度均无显著统计学差异（P0.05），偏瘫组患侧手握拳与正常组同侧手握拳所致对侧M1区激活体积差异有统计学意义（P0.05），而激活强度差异无统计学意义（P0.05）。结论：BOLD-fMRI能准确定位及定量分析感兴趣脑功能区的激活体积及强度，为判断急性脑梗死后运动功能的改变提供了一种简单有效的方法。
[Abstract]:Objective: to quantitatively analyze the activation volume and intensity of primary motor area (M1) in healthy volunteers and patients with acute cerebral infarction hemiplegia by using blood oxygen level dependent functional magnetic resonance imaging (BOLD-fMRI). To investigate the value of BOLD-fMRI in patients with acute cerebral infarction and hemiplegia. Methods: 20 healthy volunteers (normal group) and 16 hemiplegic patients with acute cerebral infarction (hemiplegia group) were examined with BOLD-fMRI. The functional images were processed by statistical parameter map (SPM5). The activation of the whole brain was observed and the MNI coordinates and anatomic distribution of the maximum signal intensity of the whole brain were obtained by xjView8 software. At the same time, M1 region was selected as the region of interest (ROI),). SPSS19.0 was used to quantitatively analyze the activation volume and intensity of M1 region. Results: two normal subjects and three hemiplegic subjects were excluded because the head-motion correction results suggested that the head-motion amplitude control was not satisfactory. With the exception of 2 hemiplegic subjects who had no activation in the whole brain of the affected hand grip, the whole brain of the normal and hemiplegic subjects with one hand clenched fist was scattered in the whole brain, and all of them were activated obviously in the contralateral M1 area. There was no significant difference in activation volume and activation intensity between normal group and hemiplegic group in contralateral M1 area (P0.05), while there were significant differences in activation volume and activation intensity between healthy hand grip and affected hand grip in hemiplegia group (P0.05). There was no significant difference in the activation volume and intensity of the contralateral M1 area between the hemiplegic group and the normal group (P0.05). There was significant difference in activation volume of contralateral M1 area between hemiplegic group and normal group (P0.05), but there was no significant difference in activation intensity between hemiplegic group and normal group (P0.05). Conclusion: BOLD-fMRI can accurately locate and quantitatively analyze the activation volume and intensity of the cerebral functional area of interest, which provides a simple and effective method for judging the changes of motor function after acute cerebral infarction.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R445.2;R743.3

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