重症急性胰腺继发感染患者区域灌注与全身给药的治疗效果观察

发布时间：2019-05-09 13:16

【摘要】：目的探讨急性胰腺炎继发感染患者区域灌注和全身给药的治疗效果,以了解区域灌注对继发感染患者炎性因子、肝肾功能及血糖等的影响,旨在提高重症急性胰腺继发感染的临床疗效。方法收集医院2013年1月-2015年1月收治的重症胰腺炎继发感染患者76例,将其按照随机单盲取法分为对照组和观察组,各38例;对照组采用全身给药治疗,观察组在常规治疗基础上给予区域灌注治疗,观察两组患者治疗前及治疗3d谷丙转氨酶(ALT)、血肌酐(Scr)、血淀粉酶(AMY)、血糖、胰高血糖素及肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)的治疗效果。结果两组患者治疗前各项观察指标对比,差异无统计学意义;治疗后观察组各项指标均低于同组治疗前及对照组治疗后(P0.05);观察组患者治疗总有效率100.00%,高于对照组81.58%,差异有统计学意义(P0.05)。结论区域灌注对重症急性胰腺炎继发感染患者疗效优于全身给药,可迅速改善急性胰腺炎指标、改善血糖及胰高血糖素水平、降低炎性因子,值得临床推广。
[Abstract]:Objective to investigate the effect of regional perfusion and systemic administration on inflammatory factors, liver and kidney function and blood glucose in patients with secondary infection of acute pancreatitis (AP), and to explore the effects of regional perfusion on inflammatory factors, liver and kidney function and blood glucose in patients with secondary infection. The purpose of this study was to improve the clinical efficacy of severe acute pancreatic secondary infection. Methods from January 2013 to January 2015, 76 patients with severe pancreatitis secondary infection were randomly divided into two groups: control group (n = 38) and observation group (n = 38). The patients in the control group were treated with systemic administration, and the patients in the observation group were given regional perfusion therapy on the basis of routine treatment. The blood glucose of serum creatinine (Scr), amylase (AMY), was observed before and 3 days after treatment in the two groups of patients with glutamic pyruvic transaminase (ALT),. The therapeutic effects of glucagon and tumor necrosis factor-伪 (TNF- 伪), interleukin-8 (IL-8), interleukin-6 (IL-6) and C-reactive protein (CRP) were observed. Results there was no significant difference between the two groups before treatment, but the indexes in the observation group after treatment were lower than those in the same group before treatment and after treatment in the control group (P0.05). The total effective rate of the patients in the observation group was 100.00%, which was higher than that in the control group (81.58%), the difference was statistically significant (P0.05). Conclusion Regional perfusion is superior to systemic administration in the treatment of severe acute pancreatitis secondary infection. It can rapidly improve the index of acute pancreatitis, improve the level of blood glucose and glucagon, and reduce the inflammatory factors, which is worthy of clinical popularization.
【作者单位】：新乡市中心医院介入科;
【基金】：河南省教育厅科学技术研究重点基金资助项目(123702322245)
【分类号】：R657.51

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