早期应用瑞舒伐他汀对急性心肌梗死患者血清心肌营养素-1水平及心功能的影响

发布时间：2019-08-11 13:27

【摘要】：目的探讨早期应用瑞舒伐他汀治疗对急性心肌梗死(AMI)患者血清心肌营养素(CT)-1水平及心功能的影响。方法 112例AMI患者随机分为两组:瑞舒伐他汀常规剂量治疗组(A组):在常规应用阿司匹林、氯吡格雷、硝酸盐类、β受体阻滞剂等药物治疗基础上加服瑞舒伐他汀10 mg/d;瑞舒伐他汀强化治疗组(B组):在常规药物治疗基础上加服瑞舒伐他汀20 mg/d。另选体检正常者40例作为对照组。对照组、AMI组用药前、用药后4 w空腹静脉采血检测CT-1水平及超声心动图指标,包括左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)值。结果 AMI组患者用药前CT-1水平较对照组明显升高(P0.05),心功能明显低于对照组(P0.05);A、B两组AMI患者于用药4 w后血浆CT-1水平及超声心动图指标较用药前明显好转,且B组改善更为明显,表现为CT-1水平明显下降(P0.05),LVEDD及LVESD明显缩小,LVEF值明显升高。结论早期应用瑞舒伐他汀治疗可有效抑制心室重塑,从而改善患者心功能及远期预后。
[Abstract]:Objective to investigate the effect of early treatment with resuvarastatin on serum myocardial nutrient (CT)-1 level and cardiac function in patients with acute myocardial infarction (AMI). Methods 112patients with AMI were randomly divided into two groups: group A: treated with aspirin, clopidogrel, nitrate, 尾 receptor blocker and other drugs: group B was treated with resuvarastatin 10 mg/d; and 20 mg/d. on the basis of routine drug therapy. Another 40 cases with normal physical examination were selected as the control group. In the control group, AMI group, fasting venous blood samples were collected 4 weeks after treatment to detect CT-1 level and echocardiography, including left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD),) left ventricular ejection fraction (LVEF). Results the level of CT-1 in AMI group was significantly higher than that in control group (P 0.05), and the cardiac function was significantly lower than that in control group (P 0.05). A, the plasma CT-1 level and echocardiography index in group B were significantly improved after 4 weeks of treatment, and the improvement in group B was more obvious, showing that the level of CT-1 decreased significantly (P 0.05), LVEDD and LVESD decreased significantly, and the value of CT-1 increased significantly. Conclusion early treatment with resuvarastatin can effectively inhibit ventricular remodeling and improve cardiac function and long-term prognosis.
【作者单位】：河北大学附属医院心血管内科;
【基金】：河北省科技支撑计划项目(No.112761123) 河北省科学技术成果(No.20140270)
【分类号】：R542.22

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