SUZ12蛋白对口腔鳞状细胞癌的致癌作用

发布时间：2018-02-04 11:07

本文关键词： 口腔鳞状细胞癌 SUZ 表观遗传学　出处：《哈尔滨医科大学学报》2014年04期 　论文类型：期刊论文

【摘要】：目的分析SUZ12蛋白的表达水平与口腔鳞状细胞癌(OSCC)患者恶性生物学行为的关系,并研究SUZ12蛋白在口腔鳞状细胞癌细胞系中的生物学功能。方法对2008至2013年哈尔滨医科大学附属第一医院96例口腔鳞状细胞癌患者石蜡标本通过免疫组化方法检测SUZ12蛋白的表达;在体外实验中,通过RNA干扰的手段抑制SUZ12蛋白在口腔鳞状细胞癌细胞系中的表达水平。结果 SUZ12蛋白在OSCC组织中表达增高,其增高与肿瘤的分化,淋巴结转移相关(P0.001);此外,发现抑制SUZ12蛋白的表达抑制了口腔鳞状细胞癌细胞的增殖,促进了口腔鳞状细胞癌细胞的凋亡。结论SUZ12起到癌基因的作用,高表达的SUZ12蛋白水平在口腔鳞状细胞癌发生发展过程中起到重要作用。
[Abstract]:Objective to analyze the relationship between the expression of SUZ12 protein and malignant biological behavior in oral squamous cell carcinoma (OSCC) patients. To study the biological function of SUZ12 protein in oral squamous cell carcinoma cell line. Methods from 2008 to 2013, 96 patients with oral squamous cell carcinoma were treated with paraffin wax in the first affiliated Hospital of Harbin Medical University. The expression of SUZ12 protein was detected by immunohistochemistry. The expression of SUZ12 protein in oral squamous cell carcinoma cell line was inhibited by RNA interference in vitro. Results the expression of SUZ12 protein was increased in OSCC tissue. Its elevation was associated with tumor differentiation and lymph node metastasis (P 0.001). In addition, it was found that inhibiting the expression of SUZ12 protein inhibited the proliferation of oral squamous cell carcinoma cells and promoted the apoptosis of oral squamous cell carcinoma cells. Conclusion SUZ12 plays a role in oncogene. Overexpression of SUZ12 protein plays an important role in the development of oral squamous cell carcinoma.
【作者单位】：哈尔滨医科大学口腔医学院牙体牙髓病科;
【分类号】：R739.85
【正文快照】： 口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)是世界范围内常见的恶性肿瘤,患者5年生存率接近50%[1]。OSCC的发生发展包括了多个基因及信号通路的改变,包括RAS基因、表皮生长因子受体、MYC、survivin和Cyclin D1等[2-4]。上述基因的异常表达或突变和OSCC的增殖分化及侵

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