酪蛋白磷酸肽-无定型磷酸钙凝胶治疗釉质脱矿效果的系统评价

发布时间：2018-04-04 00:15

本文选题：酪蛋白磷酸肽-无定形磷酸钙　切入点：随机对照试验　出处：《华西口腔医学杂志》2017年06期

【摘要】：目的对有关酪蛋白磷酸肽(CPP)-无定形磷酸钙(ACP)凝胶对于釉质脱矿治疗的随机对照试验(RCT)进行系统评价,评价其治疗的效果。方法依照Cochrane系统评价员手册(5.1.0版本)指导进行分析,包含检索策略、纳入排除标准、数据提取及质量评价。通过计算机检索Pub Med、Embase、Cochrane Library、中国知网(CNKI)、万方、维普(VIP)数据库,查找有关CPP-ACP的RCT,检索时间截至2016年9月。由2位研究者独立根据纳入与排除标准进行文献筛选、资料提取和质量评价后,对纳入研究进行系统评价。结果共纳入12个RCT,各文献中的实验设计、评价标准差异较大无法进行定量分析。结论尚无有力证据表明,CPP-ACP比常规含氟制剂存在优越性;但纳入研究数量、随访时间、设计存在局限性,且样本量较小,仍需更多高质量、长时间随访、大样本的RCT以进一步验证。
[Abstract]:Objective to evaluate the therapeutic effect of casein phosphopeptide (CPP)-amorphous calcium phosphate (ACPP) gel on enamel demineralization in a randomized controlled trial (RCTs).Methods according to the guidance of Cochrane system evaluator manual version 5.1.0, the analysis included retrieval strategy, inclusion of exclusion criteria, data extraction and quality evaluation.A computer search was carried out to search the Pub Medsite Embase Cochrane Library database. The search time was up to September 2016, and the search time was up to September 2016.According to the criteria of inclusion and exclusion, two researchers independently carried out literature screening, data extraction and quality evaluation, and then carried out a systematic evaluation of the inclusion study.Results 12 RCTs were included in the experiment design of each literature, and the difference of evaluation criteria could not be quantitatively analyzed.Conclusion there is no strong evidence that CPP-ACP is superior to conventional fluorine-containing preparations, but the number of studies included, follow-up time, design limitations, and sample size are small, still need more high quality, long follow-up.Large sample RCT for further verification.
【作者单位】：北京大学口腔医院儿童口腔科;
【分类号】：R781.1

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