HIF-1α的表达与舌鳞状细胞癌关系的系统评价

发布时间：2018-05-02 16:30

本文选题：HIF-α + 舌鳞状细胞癌(TSCC)　；参考：《实用口腔医学杂志》2014年03期

【摘要】：目的:系统评价乏氧诱导因子-1α(HIF-1α)的表达与舌鳞状细胞癌(TSCC)的关系。方法:计算机检索PubMed、EMbase、ISI Web of Knowledge系列数据库、中国生物医学文献数据库(CBM)、维普(VIP)、中国期刊网全文数据库(CNKI)、万方数据,结合手工检索,查找时间从建库至2013-04,纳入HIF-1α的表达与TSCC关系的临床研究,文献由2位研究者按照事先制定的纳入和排除标准筛选,提取资料,质量评价后,用RevMan 5.2软件进行meta分析。结果:共纳入9个研究(702例患者),meta分析结果显示:HIF-1α的表达在TSCC组高于正常对照组(OR=10.42,P0.000 01)。HIF-1α的表达在T1-T2期低于T3-T4期(OR=0.29,P0.000 01)、临床分期I-II期低于III-IV期(OR=0.12,P0.000 01)、淋巴结无转移组低于有转移组(OR=0.30,P=0.002)。病理检测高分化组与中低分化组HIF-1α的表达差异无统计学意义(OR=0.41,P=0.08)。结论:HIF-1α在TSCC中高表达,增加其恶性行为的发生风险。
[Abstract]:Objective: to systematically evaluate the relationship between the expression of hypoxia inducible factor -1 alpha (HIF-1 alpha) and the squamous cell carcinoma of the tongue (TSCC). Methods: a computer retrieval of PubMed, EMbase, ISI Web of Knowledge series database, Chinese biomedical literature database (CBM), VP (VIP), Chinese Journal network full text database (CNKI), Wanfang Data, manual retrieval, search time The clinical study of the expression of HIF-1 alpha and the relationship between TSCC and TSCC was studied. The literature was conducted by 2 researchers in accordance with pre established inclusion and exclusion criteria, extraction of data, and quality evaluation, and RevMan 5.2 software for meta analysis. Results: a total of 9 studies (702 patients) were included. The results of meta analysis showed that the expression of HIF-1 alpha was in TSCC The expression of.HIF-1 alpha in the group (OR=10.42, P0.000 01) was lower than that in the T3-T4 phase (OR=0.29, P0.000 01) in the T1-T2 phase (OR=0.29, P0.000 01), and the clinical stage I-II stage was lower than III-IV (OR=0.12, P0.000 01), and the lymph node no metastasis group was lower than that of the metastatic group (OR=0.30,). There was no statistical difference between the pathological examination and the middle and low differentiation group. (OR=0.41, P=0.08). Conclusion: HIF-1 alpha is highly expressed in TSCC, which increases the risk of malignant behavior.

【作者单位】：兰州大学第一医院口腔颌面外科;兰州大学第一医院重症医学科;
【基金】：甘肃卫生行业科研计划项目(编号:GSWST2010-04)
【分类号】：R739.8

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