西吡氯铵含片对口臭致臭菌和致臭底物作用的实验研究

发布时间：2018-05-09 04:05

本文选题：西吡氯铵 + 口臭　；参考：《第三军医大学学报》2014年16期

【摘要】：目的通过西吡氯铵含片对口源性口臭致臭菌和致臭底物的实验研究,探讨西吡氯铵含片对口源性口臭治疗的效果。方法通过连续稀释法检测西吡氯铵对致臭菌牙龈卟啉单胞菌(P.gingivalis,Pg)、中间普雷沃菌(P.intermedius,Pi)、具核梭杆菌(F.subsp nucleatum,Fn)和口腔正常有益菌唾液链球菌(Streptococcus salivarius,Ss)的最低抑菌浓度(minimal Inhibitory Concentration,MIC);并检测西吡氯铵对3种致臭菌分别培养4 h和8 h后的挥发性硫化物(volatile sulfur compounds,VSCs)水平的影响;进一步通过半胱氨酸激发模拟口臭实验,检测西吡氯铵含片对激发的VSCs的抑制率和持续时间。结果西吡氯铵对所有实验菌具有抑菌能力,但对唾液链球菌MIC值均高于其对致臭菌的MIC值;1%西吡氯铵与1%氯己定在作用Pg、Pi和Fn 4 h时,抑制作用相当(P0.05),但在作用8 h时,抑制作用西吡氯铵低于氯己定(P0.05);半胱氨酸激发模拟口臭实验结果显示,西吡氯铵含片在30~120 min内对VSCs水平的抑制率与1%聚维酮碘漱口液相当(P0.05),在60~120 min内高于西吡氯铵漱口液(P0.05)。且西吡氯铵含片下调半胱氨酸激发的VSCs水平的持续时间为235 min,长于西吡氯铵漱口液,差异有统计学意义(P0.05)。结论西吡氯铵含片能有效抑制口腔致臭菌,对治疗口源性口臭有良好的效果。
[Abstract]:Objective to investigate the efficacy of cipiramide buccal tablets in the treatment of oral halitosis. Methods the minimum Inhibitory concentration (minimal Inhibitory Concentration mice) of cepiramide against P. gingivalis, P. intermedius Pignum, F. nucleatum Fn. and Streptococcus salivus Ss. were determined by continuous dilution method. Effects of ammonium pyridine on volatile sulfur compounds (VSCs) levels of volatile sulphide compounds cultured for 4 h and 8 h, respectively. Furthermore, the inhibition rate and duration of cepiramide buccal tablets on stimulated VSCs were determined by cysteine stimulated simulated halitosis experiment. Results the bacteriostasis ability of cetylpyridinium chloride on all experimental bacteria was higher than that on Streptococcus saliva by MIC value of 1% ceftripimide and 1% chlorhexidine for 4 h, the inhibitory effect was similar to that of P0. 05% P0. 05, but at 8 h, the inhibitory effect of cipiramide on Streptococcus salivary was similar to that of 1% chlorhexidine in the presence of PgN Pi and FN for 4 h. The inhibitory effect of cetylpyridinium chloride was lower than that of chlorhexidine P0.05.The result of cysteine stimulated simulated halitosis experiment showed that the inhibitory rate of cetylpyridinium chloride buccal tablet on VSCs level was the same as that of 1% povidone iodine gargle in 30 ~ 120 min, and was higher than that of cipiramide gargle in 60 ~ 120 min. The duration of the down-regulation of cysteine-induced VSCs level was 235min, which was longer than that of cipiramine gargle (P 0.05). Conclusion Xipiramide buccal tablet can effectively inhibit oral odorific bacteria and has a good effect on oral halitosis.
【作者单位】：湖北民族学院附属民大医院口腔科;南方医科大学附属口腔医院·广东省口腔医院;
【分类号】：R781.9

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