模式识别受体和病原体相关分子模式及其在牙周病防御中的作用

发布时间：2018-05-15 17:55

本文选题：病原体相关分子模式 + 模式识别受体　；参考：《国际口腔医学杂志》2016年02期

【摘要】：模式识别受体(PRR)是宿主抵抗病原微生物的感应器,可识别一种或多种病原体相关分子模式(PAMP),可及时向下游通路转导信号,引发先天性免疫反应。PAMP包括脂多糖(LPS)、脂磷壁酸、肽聚糖和甘露糖等。不同的PAMP可被不同的Toll样受体(TLR)识别或组合识别,然后通过一系列蛋白质级联反应激活细胞因子,从而有效地活化天然免疫系统。PAMP作用于TLR后,可促进炎性细胞因子的合成与释放;诱导一氧化氮依赖性杀菌活性和呼吸爆发;介导由细菌脂蛋白引起的人单核细胞系和表达TLR2的上皮细胞系程序性细胞死亡;LPS通过作用于TLR4促进树突细胞成熟,诱导TLR2的合成与表达,进而分泌白细胞介素-6等细胞因子。对TLR的研究将有助于认识慢性牙周病并为其治疗提供新的方法,故本文就牙龈上皮表面的PRR和牙周致病菌表面的PAMP及其在牙周病中的防御作用等研究进展作一综述。
[Abstract]:The pattern recognition receptor (PRR) is the host resistant to pathogenic microorganism, which recognizes one or more pathogen associated molecular patterns (PAMP), which can transmit signals to the downstream pathway in time, triggering the congenital immune response.PAMP including lipopolysaccharide (LPS), lipophosphoric acid, peptide and mannose. Different PAMP can be different Toll like receptor (TLR). Identification or combination recognition, then activating cytokine through a series of protein cascade reactions, effectively activates the action of the natural immune system.PAMP to TLR, promotes the synthesis and release of inflammatory cytokines, induces nitric oxide dependent bactericidal activity and respiratory burst, mediates human mononuclear cell lines caused by bacterial lipoprotein and The epithelial cells expressing TLR2 are programmed cell death; LPS promotes the maturation of dendritic cells by acting on TLR4, induces the synthesis and expression of TLR2, and then secretes cytokines such as interleukin -6. The study of TLR will help to understand the chronic periodontitis and provide a new method for its treatment. Therefore, this article is about the PRR and periodontitis on the surface of the gingival epithelium. The research progress of PAMP on the surface of pathogenic bacteria and its defense function in periodontal disease are reviewed.

【作者单位】：山东大学口腔医院牙周科山东省口腔组织再生重点实验室;
【分类号】：R781.4

【参考文献】