MIF、Cyr61和Livin在人牙龈癌中的表达及临床意义

发布时间：2018-05-28 04:32

本文选题：牙龈癌 + 巨噬细胞移动抑制因子　；参考：《中国地方病防治杂志》2017年06期

【摘要】：目的分析巨噬细胞移动抑制因子(MIF)、富含半胱氨酸蛋白61(Cyr61)和凋亡抑制蛋白(Livin)在人牙龈癌中的表达及临床意义。方法收集牙龈癌蜡块标本35例(高分化15例,中分化12例,低分化8例),正常牙龈组织15例。采用免疫组化法检测石蜡标本MIF、Cyr61、Livin蛋白。结果经单因素方差分析,4种标本类型MIF、Cyr61、Livin蛋白表达水平比较差异显著(P0.05);且高分化、中分化及低分化牙龈组织MIF、Cyr61、Livin蛋白水平均高于正常牙龈组织(P0.05);牙龈癌组织MIF、Cyr61、Livin蛋白阳性率均高于正常牙龈组织(P0.05)。结论 MIF、Cyr61和Livin在人牙龈癌中高表达,且阳性检出率较高,可为牙龈癌治疗及预后提供指导。
[Abstract]:Objective to investigate the expression and clinical significance of macrophage migration inhibitory factor (MIF), cysteine-rich protein (61) and apoptosis inhibitor protein (Livin) in human gingival carcinoma. Methods 35 cases (15 cases of high differentiation, 12 cases of middle differentiation, 8 cases of low differentiation) and 15 cases of normal gingival tissue were collected. Immunohistochemical method was used to detect MIFU Cyr61 Livin protein in paraffin specimens. Results there were significant differences in the expression level of MIFG Cyr61 Livin protein among the four specimens by univariate analysis of variance (ANOVA), and the expression level of MIFG Cyr61 Livin protein was significantly different from that of P0.05, and was highly differentiated. The expression of MIFU Cyr61 Livin protein in moderately differentiated and poorly differentiated gingival tissues was higher than that in normal gingival tissues (P 0.05), and the positive rate of MIF Cyr61 livin protein in gingival cancer tissues was higher than that in normal gingival tissues. Conclusion MIF Cyr61 and Livin are highly expressed in human gingival carcinoma, and the positive rate is high, which can provide guidance for the treatment and prognosis of gingival cancer.
【作者单位】：承德医学院附属医院;
【基金】：2015年承德市科学技术研究与发展计划项目(编号20157036)
【分类号】：R739.8

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