脂肪酸去饱和酶1基因多态性、深海鱼油及其交互作用与口腔鳞状细胞癌的关系

发布时间：2018-06-20 21:42

本文选题：口腔鳞状细胞癌 + 脂肪酸去饱和酶　；参考：《卫生研究》2017年06期

【摘要】：目的探讨脂肪酸去饱和酶1(FADS1)基因多态性、深海鱼油摄入及其交互作用与口腔鳞状细胞癌(OSCC)的关系。方法 2010年9月—2014年9月,采用病例-对照研究设计,收集福建医科大学附属第一医院经病理确诊的口腔鳞状细胞癌新发病例259例和按年龄、性别频数匹配的对照538例,采用自制调查表收集研究对象的一般情况、饮食习惯如深海鱼油摄入情况等资料,利用Taq Man SNP探针检测FADS1 rs174549基因型。应用非条件Logistic回归模型评估FADS1 rs174549基因多态性与深海鱼油摄入对口腔鳞状细胞癌发病风险的影响,并进行基因-环境交互作用分析。结果携带FADS1 rs174549 AA基因型可显著降低口腔鳞状细胞癌的发生风险(共显性模型:OR=0.53,95%CI 0.33~0.85;隐性模型:OR=0.57,95%CI 0.38~0.87)。与未补充深海鱼油者相比,规律地补充深海鱼油可以降低OSCC的发生风险(OR=0.54,95%CI 0.32~0.91)。此外,FADS1 rs174549基因多态性与补充深海鱼油之间存在正相乘交互作用(OR_(相乘)=0.31,95%CI 0.11~0.87)。结论FADS1rs174549 AA基因型和深海鱼油摄入是口腔鳞状细胞癌发生的保护因素,且二者之间存在相乘交互作用。
[Abstract]:Objective to investigate the relationship between fatty acid desaturase 1 (FADS 1) gene polymorphism, deep-sea fish oil intake and its interaction with oral squamous cell carcinoma (OSCC). Methods from September 2010 to September 2014, 259 new cases of oral squamous cell carcinoma and 538 cases matched by age and sex were collected from the first affiliated Hospital of Fujian Medical University. A self-made questionnaire was used to collect the general information of the subjects and diet habits such as the intake of deep-sea fish oil. The FADS1 rs174549 genotype was detected by Taq Man SNP probe. The effects of FADS1 rs174549 gene polymorphism and deep-sea fish oil intake on the risk of oral squamous cell carcinoma were evaluated by non-conditional logistic regression model, and the gene-environment interaction was analyzed. Results carrying FADS1 rs174549 AA genotype could significantly reduce the risk of oral squamous cell carcinoma (codominant model: 1: 0. 53 + 95 CI 0.330.85; recessive model: 1: 1: 0. 57% CI 0. 38 + 0. 87). Compared with those who did not supplement deep-sea fish oil, regular supplement of deep-sea fish oil can reduce the risk of OSCC. In addition, there was a positive multiplicative interaction between FADS1 rs174549 gene polymorphism and deep-sea fish oil supplementation. Conclusion FADS1rs174549AA genotype and deep-sea fish oil intake are protective factors for oral squamous cell carcinoma, and there is a multiplicative interaction between them.
【作者单位】：福建医科大学公共卫生学院流行病与卫生统计学系;福建医科大学附属第一医院口腔颌面外科;
【基金】：福建省“大学生创新创业训练计划”项目(No.201510392072) 福建省科技厅科研项目(No.2015J01304)
【分类号】：R739.8

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