慢性牙周炎患者种植修复后龈沟液中IL-1及IL-6的水平变化研究

发布时间：2018-09-09 17:37

【摘要】：目的:通过观察慢性牙周炎患者行牙种植修复后一年内的临床效果及IL-1及IL-6的水平的变化,探讨慢性牙周炎和种植体周围炎的相关性,为慢性牙周炎患者种植修复提供理论基础。方法:随机选择18例慢性牙周炎患者的28颗种植牙为A组,15例牙周健康者的20颗种植牙为B组,对A、B两组种植牙修复后1、3、6、12个月检测种植牙的改良菌斑指数(m PLI)、改良龈沟出血指数(m SBI)、探诊深度(PD)及边缘骨吸收(MBL)量,采用ELISA法检测龈沟液中IL-1β和IL-6的含量,同时记录种植修复后一年种植体的存留率。采用SPSS17.0统计软件包对实验相关数据进行统计学分析。结果:一年内两组种植体存留率100%。横向比较结果:1.慢性牙周炎组和牙周健康组的m PLI,MBL、IL-6的含量在种植修复后3个月时开始差异有统计学意义。而两组的m SBI和PD在种植修复后1个月和3个月差异无统计学意义,6个月开始差异有统计学意义。纵向比较结果:1.两组的改良菌斑指数(m PLI)差别无统计学意义,改变幅度相同。2.两组IL-1β的含量差别有统计学意义,改变幅度相同。3.种植修复后3个月开始,慢性牙周炎组种植体龈沟液中IL-6含量的改变幅度大于牙周健康组4.两组m SBI、MBL、PD在种植修复后6个月开始差异有统计学意义,且慢性牙周炎组改变幅度大于牙周健康组。结论:1.慢性牙周炎牙列缺损种植修复短期内可以获得良好的临床疗效。2.慢性牙周炎种植患者羁患种植体周围炎的风险更大,行种植义齿修复需谨慎!3.种植义齿修复后尤其是慢性牙周炎种植患者早期就应注重种植义齿的清洁维护,有助于提高种植义齿的远期成功率
[Abstract]:Objective: to investigate the correlation between chronic periodontitis and peri-implant periodontitis by observing the clinical effect and the changes of IL-1 and IL-6 in patients with chronic periodontitis within one year after dental implant repair. To provide a theoretical basis for implant repair in patients with chronic periodontitis. Methods: Twenty-eight implants of 18 patients with chronic periodontitis were randomly selected as group A and 20 implants of 15 healthy people as group B. The modified plaque index (m PLI), modified gingival sulcus bleeding index (m SBI), probing depth (PD) and marginal bone resorption (MBL) were detected at 12 months after implant restoration in group A and B, and the contents of IL-1 尾 and IL-6 in gingival crevicular fluid were detected by ELISA method. At the same time, the survival rate of implant was recorded one year after implant restoration. The experimental data were analyzed by SPSS17.0 software package. Results: the survival rate of implants in two groups was 100% within one year. Horizontal comparison: 1. The content of m PLI,MBL,IL-6 in chronic periodontitis group and periodontal health group was significantly different 3 months after implant repair. However, there was no significant difference in m SBI and PD between the two groups at 1 month and 3 months after implant repair, but there was a significant difference between the two groups at the beginning of 6 months. Vertical comparison: 1. There was no significant difference in improved plaque index (m PLI) between the two groups. The difference of IL-1 尾 content between the two groups was statistically significant, the range of change was the same. 3. 3. The change of IL-6 content in gingival crevicular fluid in chronic periodontitis group was greater than that in healthy periodontal group 3 months after implantation. There was significant difference in m SBI,MBL,PD between the two groups at the beginning of 6 months after implant repair, and the change of m SBI,MBL,PD in chronic periodontitis group was larger than that in healthy periodontal group. Conclusion 1. In the short term, the implant repair of chronic periodontitis dentition defect can obtain good clinical effect. 2. 2. Patients with chronic periodontitis are at greater risk of peri-implant inflammation. In order to improve the long-term success rate of implant denture, especially in patients with chronic periodontitis, the clean maintenance of implant denture should be paid attention to in the early stage after the restoration of implant denture, especially in patients with chronic periodontitis.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R781.42

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