口腔鳞癌组织中PDCD5、Smac的表达及与患者临床病理参数的关系

发布时间：2018-11-03 21:41

【摘要】：目的观察口腔鳞癌组织中程序性细胞死亡蛋白5(PDCD5)、第二线粒体源性激活半胱天冬酶(Smac)的表达变化,并探讨其与患者临床病理参数的关系。方法口腔鳞癌患者55例,取其癌组织及癌旁组织(距癌组织2 cm)55例份。应用免疫组化SP法检测患者口腔鳞癌组织、癌旁组织PDCD5、Smac蛋白表达,分析PDCD5、Smac蛋白表达与口腔鳞癌患者临床病理参数的关系。结果口腔鳞癌组织中PDCD5、Smac蛋白表达阳性率低于癌旁组织(P均0.05)。口腔鳞癌组织中PDCD5、Smac蛋白表达阳性率与肿瘤的TNM分期以及淋巴结转移有关(P均0.05),与肿瘤的分化程度无关(P均0.05);PDCD5与Smac蛋白表达呈正相关(r_s=0.542,P0.05)。结论口腔鳞癌组织中PDCD5、Smac蛋白表达降低,其二者低表达协同参与口腔鳞癌的发生发展。
[Abstract]:Objective to investigate the expression of programmed cell death protein 5 (PDCD5) and mitochondrial activated cysteinase (caspase) (Smac) in oral squamous cell carcinoma (OSCC) and its relationship with clinicopathological parameters. Methods 55 cases of oral squamous cell carcinoma (OSCC) were collected from 55 cases of cancer tissues and adjacent tissues (2 cm from carcinoma). Immunohistochemical SP method was used to detect the expression of PDCD5,Smac protein in oral squamous cell carcinoma and adjacent tissues. The relationship between the expression of PDCD5,Smac protein and clinicopathological parameters of patients with oral squamous cell carcinoma was analyzed. Results the positive rate of PDCD5,Smac protein expression in oral squamous cell carcinoma was lower than that in paracancerous tissue (P 0.05). The positive rate of PDCD5,Smac protein expression in oral squamous cell carcinoma was related to the TNM stage and lymph node metastasis of the tumor (P 0.05), but not to the degree of differentiation of the tumor (P 0.05). There was a positive correlation between PDCD5 and Smac protein expression (P 0.05). Conclusion the expression of PDCD5,Smac protein in oral squamous cell carcinoma (OSCC) was decreased, and their low expression was associated with the development of OSCC.
【作者单位】：沧州医学高等专科学校;沧州市人民医院;
【基金】：河北省科技计划项目(162777266)
【分类号】：R739.8

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