牙龈癌中VEGF及PTEN的表达及其相关性分析

发布时间：2019-03-08 09:06

【摘要】：目的:研究血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)及张力蛋白同源基因(phosphatase and tensin homolog,PTEN)在牙龈癌中的表达及相关性,为临床治疗提供依据。方法:免疫组织化学S-P法研究66例牙龈癌(高分化31例,中分化20例,低分化15例)患者和15例癌旁正常组织的VEGF及PTEN的表达情况,应用SPSS13.0软件包分析2种因子的表达与临床特征之间的相关性。结果:癌旁正常组织中PTEN的阳性率高于其他各组,差异具有统计学意义(P0.05)。低分化组中VEGF的阳性率最高,与其余组比较差异显著(P0.05)。相关性研究结果显示,VEGF与复发和淋巴结转移呈正相关(P0.05);PTEN与复发和淋巴结转移呈负相关(P0.05);VEGF与PTEN在牙龈癌中的表达呈明显负相关(P0.05)。结论:VEGF表达增加和PTEN表达降低可能在牙龈癌发生、发展过程中共同发生作用。
[Abstract]:Aim: to study the expression and correlation of vascular endothelial growth factor (vascular endothelial growth factor,VEGF) and tensin homologue (phosphatase and tensin homolog,PTEN) in gingival carcinoma in order to provide evidence for clinical treatment. Methods: the expression of VEGF and PTEN in 66 cases of gingival carcinoma (31 cases with high differentiation, 20 cases with moderate differentiation and 15 cases with low differentiation) and 15 normal tissues adjacent to carcinoma were studied by immunohistochemical S-P method. SPSS13.0 software package was used to analyze the correlation between the expression of two factors and clinical features. Results: the positive rate of PTEN in paracancerous normal tissue was significantly higher than that in other groups (P0.05). The positive rate of VEGF was the highest in the poorly differentiated group, which was significantly higher than that in the other groups (P0.05). The results of correlation study showed that VEGF was positively correlated with recurrence and lymph node metastasis (P0.05); PTEN was negatively correlated with recurrence and lymph node metastasis) (P0.05); VEGF was negatively correlated with PTEN expression in gingival carcinoma (P0.05). Conclusion: the increased expression of VEGF and the decrease of PTEN expression may play an important role in the development of gingival carcinoma.
【作者单位】：河北联合大学口腔医学院;
【分类号】：R739.8

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