富自体浓缩生长因子纤维蛋白液在口腔骨缺损种植引导骨再生后的骨量变化

发布时间：2019-04-28 12:40

【摘要】：背景:临床上对于富自体浓缩生长因子纤维蛋白凝胶的成骨作用已有所研究,但是对富自体浓缩生长因子纤维蛋白液的研究较少。目的:通过观察富自体浓缩生长因子纤维蛋白液体应用于上前牙唇侧骨缺损种植同期引导骨再生后骨量变化,评估富自体浓缩生长因子纤维蛋白液体联合Bio-Oss骨粉在骨增量中的应用效果。方法:选取单颗上前牙缺失伴唇侧骨缺损患者50例,随机分为试验组和对照组,各25例,2组均采用种植同期引导骨再生的手术方式。试验组使用富自体浓缩生长因子纤维蛋白液体+Bio-Oss骨粉+海奥生物膜进行引导骨再生;对照组使用Bio-Oss骨粉+海奥生物膜进行引导骨再生。结果与结论:50例患者的种植体愈合情况良好,符合种植体成功的标准。种植后即刻至6个月,2组种植体各位点的唇侧骨量变化差别无显著性意义(P0.05);种植后6-12个月,试验组种植体各位点的唇侧骨量变化均小于对照组(P0.05)。提示富自体浓缩生长因子纤维蛋白液体联合Bio-Oss骨粉对上前牙缺失伴唇侧骨缺损患者种植疗效较好,富自体浓缩生长因子纤维蛋白液体对减少种植体负载后唇侧骨吸收有一定的积极作用。
[Abstract]:Background: the osteogenesis of autologous-rich growth factor-rich fibrin gels has been studied clinically, but little has been done on autogenous-rich growth factor-rich fibrin gels. Objective: to observe the changes of bone mass after bone regeneration guided by autogenous concentrated growth factor fibrin liquid in the labial bone defect of upper anterior teeth at the same time. To evaluate the effect of autologous concentrated growth factor fibrin liquid combined with Bio-Oss bone powder in bone increment. Methods: 50 patients with single anterior tooth defect and lip bone defect were randomly divided into test group and control group with 25 cases in each group. The two groups were treated with bone regeneration guided by implant at the same time. The patients were divided into two groups: experimental group (25 cases) and control group (25 cases). The autogenous concentrated growth factor-rich fibrin liquid Bio-Oss bone mineral membrane was used to guide bone regeneration in the experimental group and the control group was used in the Bio-Oss bone powder sea Olympic biomembrane to guide bone regeneration. Results & conclusion: 50 cases of implant healing were in good condition, which accorded with the criteria of implant success. From immediate to 6 months after implantation, there was no significant difference in the lip bone mass between the two groups (P0.05), while the change of the lip bone mass in the experimental group was smaller than that in the control group (P0.05) at the 6th month after the implantation (P0.05). 3. The changes of the lip bone mass in the two groups were significantly lower than those in the control group (P0.05). The results suggest that the autogenous concentrated growth factor fibrin liquid combined with Bio-Oss bone powder is effective in the treatment of upper anterior tooth loss with lip bone defect. The autogenous concentrated growth factor fibrin liquid has a positive effect on reducing the bone resorption of the posterior labium loaded on the implant.
【作者单位】：西南医科大学口腔医学院;西南医科大学附属口腔医院;
【基金】：四川省科技厅-泸州市科技局-泸州医学院联合科研项目(14JC0122-LY51) 四川省教育厅项目(11ZB128)~~
【分类号】：R783.6

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