颈内动脉持续输注丙泊酚构建肌松兔模型的药代动力学变化

发布时间：2018-06-05 05:04

本文选题：二异丙酚 + 肌松弛　；参考：《中国组织工程研究》2015年27期

【摘要】：背景:经动脉选择性脑内给药方法是现阶段提高脑内药物浓度,降低药物对其他系统功能影响的有效方法之一。目的:建立颈内动脉持续输注丙泊酚构建肌松兔模型,分析丙泊酚药物浓度变化规律。方法:颈内动脉置管进行丙泊酚恒速持续输注建立兔颈内动脉持续输注丙泊酚肌松兔模型,在不同时点取得两侧颈内动静脉血及两侧脑组织样本,应用高效液相荧光法检测药物浓度,然后将所得数据进行数学转换,拟合处理,统计学回归分析药代动力学特点。结果与结论:高效液相色谱荧光法测定丙泊酚浓度方法可行,系统稳定可靠。颈内动脉持续输注丙泊酚药物浓度增长率分析,数据分布呈对数正态分布图形,属于非指数动力学模型,即改良的对数正态分布模型,f(x)=1/k(2π)1/2σx)e-(Inx-u)2/2σ2,其中σ代表脑内药物浓度变化波动性的稳定性,与脑组织药物摄取和脑循环等多种因素有关的综合变量。说明颈内动脉持续输注丙泊酚药代动力学模型属于对数正态分布函数,属于非指数函数动力学模型。两侧脑内浓度随时间的变化规律遵循对数正态分布函数规律。
[Abstract]:Background: transarterial selective intracerebral administration is one of the effective methods to increase the concentration of drugs in the brain and reduce the effects of drugs on other system functions. Aim: to establish a rabbit model of muscle relaxation by continuous infusion of propofol through internal carotid artery, and to analyze the change of propofol concentration. Methods: the rabbit model of continuous infusion of propofol was established by continuous infusion of propofol through the internal carotid artery. The blood samples of bilateral internal carotid vein and bilateral brain tissue were obtained at different time points. The drug concentration was detected by high performance liquid phase fluorescence method, and then the data were converted, fitted, and the pharmacokinetic characteristics were analyzed by statistical regression analysis. Results & conclusion: the method of high performance liquid chromatography (HPLC) for the determination of propofol concentration is feasible and the system is stable and reliable. The analysis of the concentration growth rate of propofol by internal carotid artery infusion showed that the distribution of the data was logarithmic normal distribution pattern, which belongs to the non-exponential kinetic model. That is, the modified lognormal distribution model is a 1 / 2 蟺 ~ (-1) x)e-(Inx-u)2/2 蟽 _ 2, where 蟽 represents the stability of the fluctuation of drug concentration in the brain, and is a comprehensive variable related to many factors, such as drug uptake and cerebral circulation in brain tissue. The pharmacokinetic model of continuous infusion of propofol by internal carotid artery is a logarithmic normal distribution function and a non-exponential kinetic model. The change of brain concentration with time follows the law of logarithmic normal distribution function.
【作者单位】：中国医科大学附属盛京医院麻醉二科;沈阳药科大学数学系;
【基金】：国家自然科学基金(81071449)~~
【分类号】：R965;R-332

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