固有免疫信号分子hsa-miR-181a调节脑卒中作用的生物信息学分析

发布时间：2018-06-06 11:34

本文选题：miRNAs + 固有免疫　；参考：《现代免疫学》2015年03期

【摘要】：对固有免疫信号分子hsa-miR-181a进行生物信息学分析,以期探讨其调节脑卒中的生物学途径和信号通路,为hsamiR-181a的实验验证及功能研究提供理论指导。利用TargetScan 6.0、miRWalk、miRanda、PicTar、Genecards数据库预测所得的hsa-miR-181a与脑卒中所相关的靶基因,通过BINGO及DAVID对脑卒中相关靶基因集合进行基因本体(gene ontology,GO)和信号通路分析。hsa-miR-181a可与固有免疫基因TLR4相互作用,并同时作用于与脑卒中相关的其它靶基因,通过调节细胞途径,影响代谢过程等生物学途径,神经营养因子信号转导等KEGG信号通路发挥作用。固有免疫信号分子hsa-miR-181a可通过调节细胞途径,影响代谢过程等生物学途径,神经营养因子信号转导等信号通路调节脑卒中,为进一步实验和功能验证提供生物信息学指导。
[Abstract]:The bioinformatics analysis of the inherent immune signaling molecule hsa-miR-181a was carried out in order to explore the biological and signal pathways regulating stroke and provide theoretical guidance for the experimental verification and functional study of hsamiR-181a. The target genes of hsa-miR-181a associated with stroke were predicted by using TargetScan 6.0 / miRWalkmmiRWalkmiRRR-Genecards database. Stroke related target genes were collected by BINGO and DAVID) and signal pathway analysis was used to analyze the interaction between hsa-miR-181a and the innate immune gene TLR4, and to analyze the interaction of hsa-miR-181a with the innate immune gene TLR4 by BINGO and DAVID. At the same time, it acts on other target genes related to stroke, through regulating cell pathway, affecting metabolism and other biological pathways, and KEGG signaling pathway such as neurotrophic factor signal transduction. The intrinsic immune signaling molecule hsa-miR-181a can regulate stroke by regulating cellular pathway, affecting metabolic process, neurotrophic factor signal transduction and other signaling pathways, which provides bioinformatics guidance for further experiments and functional verification.
【作者单位】：南昌大学第一附属医院药学部;南昌大学转化医学研究院心血管疾病研究中心;
【分类号】：R392

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