大鼠应激性溃疡模型复制及埃索美拉唑的干预效果

发布时间：2018-06-09 14:04

本文选题：应激性胃溃疡 + 埃索美拉唑　；参考：《中国老年学杂志》2015年22期

【摘要】：目的复制大鼠应激性溃疡动物模型并进行预防性治疗。方法 24只大鼠随机分成3组,每组8只。实验前埃索美拉唑组灌胃埃索美拉唑2.4 mg/kg,模型组灌胃生理盐水1 ml/d,共3 d,正常对照组不做任何处理。采用冷藏法制作应激性胃溃疡大鼠模型。对比3组胃黏膜的溃疡程度并测定胃内p H值变化。结果正常对照组胃黏膜表面光滑,呈粉白色,无任何溃疡面。其他两组均有不同程度胃溃疡,以模型组溃疡程度最严重,沿着胃黏膜褶皱凸起的部位有多发的条索状出血带及点状出血,呈咖啡色,黏膜水肿、糜烂、溃疡严重;与模型组比较,埃索美拉唑组胃溃疡程度明显减轻(P0.05)。与正常对照组比较,模型组胃内p H值降低(P0.05);与模型组比较,埃索美拉唑组胃内p H值有一定程度增加。结论冷应激可用来复制大鼠胃溃疡模型,埃索美拉唑对胃溃疡具有预防作用。
[Abstract]:Objective to establish an animal model of stress ulcer in rats and to carry out preventive treatment. Methods 24 rats were randomly divided into 3 groups with 8 rats in each group. Before the experiment, esomeprazole group was given esomeprazole 2.4 mg / kg, the model group was given normal saline 1 ml / d for 3 days, the normal control group did not do any treatment. The rat model of stress gastric ulcer was made by cold storage. The degree of gastric mucosal ulcer and the changes of gastric pH were measured. Results the surface of gastric mucosa in normal control group was smooth, pink white and no ulcer surface. The other two groups had different degrees of gastric ulcer, especially the model group, the most serious ulcer, along the gastric mucous membrane fold protruding place there were multiple stripe bleeding zone and point hemorrhage, showing brown, mucosal edema, erosion, ulcer serious; Compared with the model group, esomeprazole group significantly alleviated the degree of gastric ulcer. Compared with the normal control group, the gastric pH value of the model group was lower than that of the model group, and the gastric pH value of the esomeprazole group was increased to a certain extent. Conclusion Cold stress can be used to induce gastric ulcer in rats. Esomeprazole can prevent gastric ulcer.
【作者单位】：北华大学基础医学院机能实验部;北华大学第一临床学院;
【基金】：北华大学健峰教研基金资助项目(2014062504)
【分类号】：R573.1;R-332

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