JAK2/STAT3信号转导通路在门静脉高压大鼠模型脾脏纤维化过程中的作用
发布时间：2022-02-10 15:36
脾肿大是门脉高压症的重要并发症之一[1]。据统计，大约36%-92%的肝硬化患者存在着不同程度脾脏肿大[2]，特别是在我国，乙型病毒性肝炎导致的失代偿期肝硬化是引起脾肿大的主要原因之一[3]，严重危害着患者的生命健康。门脉高压性脾脏肿大可以产生一系列的并发症[4-5]：1、压迫腹腔周围脏器产生相应症状；2、脾功能亢进导致贫血；3、导致机体免疫功能下降；4、可能因轻微碰撞而发生破裂出血；5、机体储血能力下降等。纤维组织增生是门脉高压症脾脏肿大的重要原因之一，也是其主要病理特征之一。JAK2/STAT3信号转导通路是一条多种细胞因子参与的信号转导途径，最初因为参与细胞增殖而被发现，在后续的研究中发现该信号转导通路与机体的多种组织器官的细胞分化、凋亡、免疫功能改变等密切相关[6]。有研究表明该信号转导通路可能参与机体组织器官的纤维化过程[7-12]。在肾间质纤维化过程中JAK2/STAT3信号转导通路被激活提示该通路可能参与了组织纤维化。JAK2/STAT3信号转导通路还通过调节多种细胞因子促进血管平滑肌细胞和成纤维细胞增生、迁移。既往研究表明JAK2/STAT3信号转导通路在组织纤维化过程...
【文章来源】：中国人民解放军空军军医大学陕西省211工程院校
【文章页数】：47 页
【学位级别】：硕士
【部分图文】：
JAK2蛋白晶体结构示意图
JAK2/STAT3信号传导通路激活与调控示意图
Masson三色染色结果（×200）
【参考文献】：
期刊论文
[1]Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation[J]. Ashley M Lakner,Cathy C Moore,Alyssa A Gulledge,Laura W Schrum. World Journal of Gastroenterology. 2010(40)
[2]Stability of a rat model of prehepatic portal hypertension caused by partial ligation of the portal vein[J]. Zhe Wen, Hui-Min Xia, Department of Surgery, Guangzhou Children’s Hospital Affi liated to Guangzhou Medical College, Guangzhou 510120, Guangdong Province, China Jin-Zhe Zhang, Ya-Jun Chen, Department of Surgery, Beijing Children’s Hospital Affiliated to Capital Medical University, Beijing 100045, China Chun-Xiao Yang, Department of Surgery, Linzi People’s Hospital, Zibo 255400, Shandong Province, China. World Journal of Gastroenterology. 2009(32)
[3]Clinical characteristics of idiopathic portal hypertension[J]. Ozgur Harmanci,Yusuf Bayraktar. World Journal of Gastroenterology. 2007(13)
[4]Expression of TNF-α and VEGF in the esophagus of portal hypertensive rats[J]. Zhao-Hui Yin, Xun-Yang Liu, Rang-Lang Huang, Shu-Ping Ren, Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China. World Journal of Gastroenterology. 2005(08)
[5]Immunohistochemical Analysis of Growth Factor Expression and Localization in Gastric Coronary Vein of Cirrhotic Patients[J]. YANG Zhen; TIAN Lei; PENG Lin; QIU Fazu(Department of Surgery, Tongji Hospital, Tongji Medical University Wuhan 430030). 同济医科大学学报(外文版). 1996(04)
[6]门静脉高压症巨脾原位保留与异位移植组织变化与功能的比较[J]. 汪谦,程庆君,郭金鹏. 蚌埠医学院学报. 1991(01)
本文编号：3619091
【文章来源】：中国人民解放军空军军医大学陕西省211工程院校
【文章页数】：47 页
【学位级别】：硕士
【部分图文】：
JAK2蛋白晶体结构示意图
JAK2/STAT3信号传导通路激活与调控示意图
Masson三色染色结果（×200）
【参考文献】：
期刊论文
[1]Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation[J]. Ashley M Lakner,Cathy C Moore,Alyssa A Gulledge,Laura W Schrum. World Journal of Gastroenterology. 2010(40)
[2]Stability of a rat model of prehepatic portal hypertension caused by partial ligation of the portal vein[J]. Zhe Wen, Hui-Min Xia, Department of Surgery, Guangzhou Children’s Hospital Affi liated to Guangzhou Medical College, Guangzhou 510120, Guangdong Province, China Jin-Zhe Zhang, Ya-Jun Chen, Department of Surgery, Beijing Children’s Hospital Affiliated to Capital Medical University, Beijing 100045, China Chun-Xiao Yang, Department of Surgery, Linzi People’s Hospital, Zibo 255400, Shandong Province, China. World Journal of Gastroenterology. 2009(32)
[3]Clinical characteristics of idiopathic portal hypertension[J]. Ozgur Harmanci,Yusuf Bayraktar. World Journal of Gastroenterology. 2007(13)
[4]Expression of TNF-α and VEGF in the esophagus of portal hypertensive rats[J]. Zhao-Hui Yin, Xun-Yang Liu, Rang-Lang Huang, Shu-Ping Ren, Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China. World Journal of Gastroenterology. 2005(08)
[5]Immunohistochemical Analysis of Growth Factor Expression and Localization in Gastric Coronary Vein of Cirrhotic Patients[J]. YANG Zhen; TIAN Lei; PENG Lin; QIU Fazu(Department of Surgery, Tongji Hospital, Tongji Medical University Wuhan 430030). 同济医科大学学报(外文版). 1996(04)
[6]门静脉高压症巨脾原位保留与异位移植组织变化与功能的比较[J]. 汪谦,程庆君,郭金鹏. 蚌埠医学院学报. 1991(01)
本文编号：3619091
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