脊髓损伤后Notch信号对神经再生的研究现状

发布时间：2018-01-01 03:36

本文关键词：脊髓损伤后Notch信号对神经再生的研究现状　出处：《中国康复医学杂志》2016年04期 　论文类型：期刊论文

【摘要】：正脊髓损伤(spinal cord injury,SCI)后首先表现为脊髓组织及结构直接被破坏,继而在损伤局部发生缺血、缺氧、创伤后炎症反应、细胞凋亡等一系列变化,致使神经元变性坏死、神经胶质细胞修复功能被抑制、损伤部位相连的远端轴突出现慢性脱髓鞘改变,进而导致神经功能障碍。且脊髓损伤后的炎性环境使损伤区域聚集大量胶质细胞,并分泌过多的细胞外基质,从而形成瘢痕组织,再次阻碍神经元再生及神经
[Abstract]:After spinal cord injury (cord), the spinal cord tissue and structure were destroyed directly, and then ischemia and hypoxia occurred in the injured area. A series of changes, such as post-traumatic inflammatory reaction and apoptosis, resulted in degeneration and necrosis of neurons, inhibition of the repair function of glial cells, and chronic demyelination of the distal axons connected to the injured sites. And the inflammatory environment after spinal cord injury makes the injured area gather a large number of glial cells, and secrete too much extracellular matrix, thus forming scar tissue, again blocking the regeneration of neurons and nerve
【作者单位】：辽宁医学院;辽宁医学院附属第三医院;
【基金】：辽宁医学院校长基金——奥鸿博泽研究生科研创新基金资助
【分类号】：R651.2
【正文快照】： 脊髓损伤(spinal cord injury,SCI)后首先表现为脊髓组织及结构直接被破坏,继而在损伤局部发生缺血、缺氧、创伤后炎症反应、细胞凋亡等一系列变化,致使神经元变性坏死、神经胶质细胞修复功能被抑制、损伤部位相连的远端轴突出现慢性脱髓鞘改变,进而导致神经功能障碍。且脊髓

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