大鼠模拟臀位体位与髋关节发育不良关系的实验研究

发布时间：2018-01-10 06:10

本文关键词：大鼠模拟臀位体位与髋关节发育不良关系的实验研究　出处：《中国矫形外科杂志》2016年23期 　论文类型：期刊论文

【摘要】：[目的]通过建立臀位体位动物模型模拟宫内臀位状态研究臀位体位对髋关节发育不良的影响。[方法]新生大鼠双后肢捆绑维持髋关节屈曲,膝关节伸展,模仿人类宫内臀位。实验大鼠于生后0、2、4、6、8 d处死,全骨架染色后行后前位骨盆摄像观察髋臼与股骨头的关系并测量软骨髋臼指数(CAI)、中心边缘角(CEA)及髋臼开口直径与深度的比值(D/D)。[结果]随着异常体位维持时间的延长,髋关节发育不良的发生率逐渐增多且严重程度逐渐加重。除0 d组外各实验组与对照组相比CAI明显增大,CEA减小而D/D明显增加。同时发现实验组大鼠坐骨侧方弯曲且髋臼关节软骨变薄。[结论]臀位体位导致髋关节发育不良是一由轻微发育不良至髋关节半脱位直至完全脱位的慢性过程。臀位体位维持时间越长,髋关节发育不良的发生率越高,病理改变越重。
[Abstract]:[Objective] through the new method. Effects of hind limbs of rats to establish animal model of intrauterine breech breech position of breech position of hip dysplasia bound to maintain hip flexion, knee extension, mimic the human intrauterine breech. The experimental rats were sacrificed at d 0,2,4,6,8 after birth, the whole skeleton staining was posteroanterior pelvis the camera to observe the relationship between acetabulum and femoral head cartilage and measurement of acetabular index (CAI), center edge angle (CEA) and the ratio of acetabular opening diameter and depth (D/D). Along with the prolongation of postural maintenance time, hip development gradually increased and the incidence of adverse severity gradually increased. In 0 d group the experimental group compared with the control group CAI significantly increased, CEA decreased and D/D increased significantly. At the same time that the experimental group of rat sciatic lateral bending and acetabular articular cartilage thinning. Conclusion] breech position cause hip. Is a process of chronic dysplasia by mild dysplasia and subluxation of hip dislocation. Until the breech position maintained longer, hip dysplasia incidence rate is high, the more serious the pathological changes.

【作者单位】：中国医科大学附属盛京医院小儿骨科;中国医科大学附属盛京医院骨科;
【基金】：国家自然科学基金项目(编号:81171675;30700877)
【分类号】：R726.8
【正文快照】： 发育性髋关节发育不良(developmental dysplasiaof the hip,DDH)是一类髋关节解剖发育异常的疾病,因遗传易感性及诊断方法不同,发生率在不同地区存在差异[1]。DDH危险因素包括女性、宫内臀位、第一胎及阳性家族史等,而宫内臀位胎儿DDH发生率明显增高[2~4]。之前研究通过流行病

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