谷氨酰胺治疗对有营养风险肝胆手术病人临床结局影响研究

发布时间：2018-01-14 05:32

  本文关键词：谷氨酰胺治疗对有营养风险肝胆手术病人临床结局影响研究　出处：《中国实用外科杂志》2016年01期 　论文类型：期刊论文

  更多相关文章： 肝胆手术 营养风险 谷氨酰胺

【摘要】：目的观察肝胆手术病人营养风险的发生率,探讨谷氨酰胺(Glutamine,GLn)治疗对有营养风险病人临床结局的影响。方法采用队列研究的方法,连续定点采集2011年1月至2014年12月于广州军区武汉总医院行手术治疗的肝胆外科病人资料,用NRS2002评分标准,对≥3分的病人纳入研究。共402例病人,分Gln治疗组248例和非Gln组154例,观察两组住院时间和感染性并发症发生率。结果 Gln组和非Gln组感染性并发症分别为9例、14例(P0.05),住院天数分别为(11.28±7.77)d、(12.03±9.02)d(P0.05)。NRS评分≥5分的病人,Gln组(130例)和非Gln组(47例)病人的并发症分别为4例、6例,住院时间分别为(11.21±7.15)d、(12.73±1.26)d(P0.05)。多因素logistic回归分析提示,Gln治疗是感染性并发症的保护因素,而NRS评分≥5分、术前GGT升高、术前前白蛋白降低是危险因素,其OR值分别为0.76、1.19、1.25、1.39,P值均小于0.05。结论 Gln治疗能显著降低存在营养风险肝胆外科手术病人的感染并发症发生率,且NRS评分≥5分的病人尚可缩短住院时间,更能从Gln治疗中获益。
[Abstract]:Objective to observe the incidence of nutritional risk in patients undergoing hepatobiliary surgery and to explore the effect of glutamine Glutaminel (GLnn) treatment on the clinical outcome of patients with nutritional risk. The data of hepatobiliary surgery patients who were operated on from January 2011 to December 2014 in Wuhan General Hospital of Guangzhou military region were collected continuously and the NRS2002 score was used. A total of 402 patients were divided into Gln treatment group (248 cases) and non-#en1# group (154 cases). Results Infectious complications in Gln group and non-#en1# group were 9 cases or 14 cases respectively (P0.05). The days of hospitalization were 11.28 卤7.77 days and 12.03 卤9.02 days respectively. NRS score 鈮，

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