宫颈癌切除术患者术后羟考酮静脉自控镇痛效果及免疫功能观察

发布时间：2018-01-19 06:10

本文关键词： 宫颈癌宫颈癌切除术术后镇痛羟考酮静脉自控镇痛　出处：《山东医药》2017年19期 　论文类型：期刊论文

【摘要】：目的观察羟考酮静脉自控镇痛的宫颈癌切除术患者术后镇痛情况及免疫功能。方法 60例择期行腹腔镜下宫颈癌根治术的宫颈癌患者,随机分为观察组和对照组各30例。两组均行腹腔镜下宫颈癌根治术。术后观察组采用羟考酮静脉自控镇痛,对照组采用芬太尼静脉自控镇痛,共治疗2 d。分别于术后12、24、48 h时采用视觉模拟疼痛评分(VAS)评价两组术后疼痛情况。分别于术前30 min、术后24 h、术后48 h、术后72 h采集两组外周静脉血4 m L,采用流式细胞法检测两组外周血CD3~+、CD4~+、CD8~+T细胞和NK细胞百分比;采用ELISA法检测两组血清干扰素γ(IFN-γ)、白细胞介素10(IL-10)。结果术后12、24、48 h时观察组VAS评分分别为(3.50±0.51)、(3.07±0.67)、(2.96±0.62)分,对照组分别为(3.17±0.38)、(2.93±0.58)、(2.80±0.48)分,术后12 h观察组VAS评分高于对照组,P0.05。术后48、72 h观察组外周血CD4~+、CD8~+T细胞百分比高于对照组(P均0.05),术后24、48、72 h观察组外周血NK细胞百分比高于对照组(P均0.05)。术后48、72 h观察组血清IFN-γ水平低于对照组(P均0.05)。术后24、48、72 h观察组血清IL-10水平高于对照组(P均0.05)。结论宫颈癌切除术患者术后羟考酮静脉自控镇痛效果较好。羟考酮静脉自控镇痛可改善患者术后免疫功能,减轻炎症反应。
[Abstract]:Objective to observe the postoperative analgesia and immune function in patients with cervical cancer treated by intravenous analgesia with hydroxycodone. Methods 60 patients with cervical cancer undergoing laparoscopic radical cervical cancer resection were enrolled in this study. Two groups were randomly divided into observation group (n = 30) and control group (n = 30). Laparoscopic radical resection of cervical cancer was performed in both groups. Postoperative patient-controlled analgesia with hydroxycodone was used in the observation group and fentanyl was used in the control group. The postoperative pain was evaluated by visual analogue pain score (VASS) at 12: 24 hours after operation for 2 days, 30 minutes before operation and 24 hours after operation. Peripheral venous blood was collected at 48 hours and 72 hours after operation, and peripheral blood was detected by flow cytometry. Percentage of CD8T cells and NK cells; The serum levels of IFN- 纬 and IL-10 were detected by ELISA. At 48 h, the VAS scores of the observation group were 3.50 卤0.51 and 3.07 卤0.67 respectively, and the scores were 2.96 卤0.62). The scores of VAS in the control group were 3.17 卤0.38, 2.93 卤0.58 and 2.80 卤0.48, respectively. The VAS score in the observation group was higher than that in the control group at 12 hours after operation. The percentage of CD4 ~ + CD8 ~ T cells in peripheral blood of the observation group was higher than that of the control group (P < 0.05), and the percentage of CD8 ~ T cells in the observation group was higher than that in the control group (P < 0.05). The percentage of NK cells in the observation group was higher than that in the control group (P < 0.05). The serum IFN- 纬 level in the observation group was lower than that in the control group (P < 0.05) at 72 h. The serum IL-10 level in the observation group was higher than that in the control group (P < 0.05). Conclusion the effect of PCIA in patients with cervical cancer after operation is good, and the postoperative immune function can be improved by PCIA. [WT5 "HZ] [WT5" BZ] [WT5 "BZ] [WT5" BZ]. Reduce inflammation.
【作者单位】：广西医科大学第四附属医院暨柳州市工人医院;
【基金】：广西壮族自治区卫生和计划生育委员会自筹经费科研课题(z2016186)
【分类号】：R614
【正文快照】： 宫颈癌是最常见的妇科恶性肿瘤之一,手术切除是最主要的治疗方法。但宫颈癌术后易出现转移和复发,严重影响患者预后。研究[1]认为,宫颈癌术后转移复发除了与肿瘤组织病理学、病理分期相关以外,还与肿瘤患者围术期的免疫功能密切相关。手术应激情况、麻醉因素[1]均与围术期免疫

【相似文献】