蛋白酶激活受体2在骨关节炎发病机制中的研究进展

发布时间：2018-01-29 10:19

本文关键词： 骨关节炎蛋白酶激活受体细胞因子关节疼痛　出处：《中国修复重建外科杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的综述蛋白酶激活受体2(protease-activated receptor 2,PAR-2)在骨关节炎(osteoarthritis,OA)发病机制中的研究进展。方法广泛查阅近年国内外有关PAR-2在OA发生发展过程中作用机制的文献,并进行综合分析。结果 PAR-2的异常激活在OA发生发展过程中发挥重要作用。激活的PAR-2可以通过调节炎性因子、代谢因子、致痛因子等的生成及释放,参与OA关节软骨、软骨下骨及滑膜的生理和病理变化以及疼痛的产生与传导。结论 PAR-2参与OA的发生发展已被证实,但由于PAR-2的复杂性以及分布的广泛性,需对其在OA进程中的具体作用及各通路间的相互影响进行深入研究,阐明PAR-2参与OA病变过程的潜在病理生理机制,以期探索新的有效控制OA发生的作用靶点。
[Abstract]:Objective to review the role of protease-activated receptor 2 (PAR-2) in osteoarthritis of osteoarthritis. Methods recent literatures on the role of PAR-2 in the pathogenesis of OA were reviewed. Results abnormal activation of PAR-2 plays an important role in the development of OA. Activated PAR-2 can regulate inflammatory factors and metabolic factors. The production and release of pain-causing factors are involved in the physiological and pathological changes of articular cartilage, subchondral bone and synovium, as well as the production and transmission of pain. Conclusion PAR-2 has been proved to be involved in the occurrence and development of OA. However, due to the complexity of PAR-2 and its wide distribution, it is necessary to study the specific role of PAR-2 in OA process and the interaction between different pathways. To elucidate the underlying pathophysiological mechanism of PAR-2 involved in the pathogenesis of OA in order to explore new and effective targets for the control of OA.
【作者单位】：华北理工大学附属医院骨科;河北医科大学研究生院;华北理工大学医学实验中心;
【基金】：国家自然科学基金资助项目(31671235) 河北省自然科学基金重点项目(H2016209176) 河北省政府资助临床医学优秀人才培养和基础课题研究项目(361036) 唐山市科技创新团队培养计划(15130208C) 河北省第二批青年拔尖人才支持计划~~
【分类号】：R684.3
【正文快照】： 骨关节炎(osteoarthritis,OA)是临床常见的慢性退行性疾病,主要特征是关节软骨退行性改变和丢失,其退变的速度超过修复及再生的速度,同时伴有软骨下骨损伤及滑膜炎症[1]。传统观点认为OA与衰老、性别、应力损伤等因素有关[2]。随着研究的深入,越来越多的证据表明该病还与代谢

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