氟比洛芬酯注射液联合芬太尼注射液用于老年髋关节置换术的临床研究

发布时间：2018-01-29 14:06

本文关键词： 氟比洛芬酯注射液芬太尼注射液老年髋关节置换术安全性　出处：《中国临床药理学杂志》2017年18期 　论文类型：期刊论文

【摘要】：目的观察氟比洛芬酯注射液联合芬太尼注射液用于老年髋关节置换术自控镇痛的临床疗效及安全性。方法将140例拟接受全麻下髋关节置换术老年患者随机分为对照组70例和试验组70例。对照组予以芬太尼1 mg,自控镇痛;试验组予以氟比洛芬酯50 mg+芬太尼1 mg,自控镇痛。比较2组患者的简易精神状态量表(MMSE)评分和药物不良反应的发生情况。结果术后48 h,试验组和对照组的MMSE评分分别为(28.83±1.31)和(25.73±1.65)分,差异有统计学意义(P0.05)。2组患者的药物不良反应以恶心、呕吐、皮肤瘙痒为主,试验组和对照组的药物不良反应发生率分别为8.57%和22.86%,差异有统计学意义(P0.05)。结论氟比洛芬酯注射液联合芬太尼注射液用于老年髋关节置换术的临床疗效确切,且安全性较好。
[Abstract]:Objective to observe the efficacy and safety of flurbiprofen ester injection combined with fentanyl injection in patient-controlled analgesia of hip arthroplasty in elderly patients. Methods 140 cases of elderly patients undergoing hip replacement under general anesthesia were randomly divided into two groups. Fentanyl 1 was given to control group (n = 70) and experimental group (n = 70). Mg. Patient-controlled analgesia; The experimental group was given flurbiprofen ester 50 mg fentanyl 1 mg. The MMSE scores and adverse drug reactions were compared between the two groups. Results 48 hours after operation. The MMSE scores of the test group and the control group were 28.83 卤1.31 and 25.73 卤1.65, respectively. The difference was statistically significant in the adverse drug reactions of patients with P0.052.The main adverse reactions were nausea, vomiting and itching of skin. The incidence of adverse drug reactions in the trial group and the control group was 8.57% and 22.86%, respectively. Conclusion flurbiprofen ester injection combined with fentanyl injection is effective and safe in elderly hip arthroplasty.
【作者单位】：东营市人民医院麻醉科;山东省肿瘤防治研究院;
【基金】：山东省自然科学基金资助项目(2014ZRC03085)
【分类号】：R614
【正文快照】： (1.东营市人民医院麻醉科,山东东营257091;2.山东省肿瘤防治研究院,济南250117)YANG Long-jun1,ZHANG Wei-wei2(1.Department of Anesthesiology,Dongying People’s Hospital,Dongying257091,Shandong Province,China;2.Shandong Institute of Cancer Preventionand Control,

【相似文献】