醒脑静注射液联合高压氧对重度颅脑损伤患者神经功能恢复的影响

发布时间：2018-01-30 13:37

本文关键词： 醒脑静注射液高压氧重症颅脑损伤神经功能　出处：《中药药理与临床》2017年02期 　论文类型：期刊论文

【摘要】：目的:观察醒脑静注射液联合高压氧对重度颅脑损伤患者神经功能恢复的影响。方法:2014年10月~2016年9月我院神经外科收治的68例重症颅脑损伤患者,所有患者均常规治疗基础上使用高压氧治疗,其中34例在以上治疗基础上另外加用醒脑静注射液。观察两组患者治疗后神经功能的恢复情况。结果:治疗一个月后,观察组血清ET-1、S100B和NPY水平分别为(50.58±8.79ng/L、0.41±0.10μg/L、74.5±11.4ng/L),均明显低于对照组(63.82±9.94ng/L、0.60±0.15μg/L、93.7±12.0ng/L)。治疗3个月后,观察组MMSE、NIHSS评分和记忆商值分别为(27.26±2.19分、15.89±1.49分、96.81±4.15),均明显优于对照组(23.85±2.05分、20.14±1.53分、85.99±3.96)。治疗3个月后,对照组有2例患者死亡,观察组无死亡患者,观察组预后良好(IV+V)比例为50.00%,明显高于对照组26.47%。(4)对照组患者治疗期间发生20例(58.82%)肺部感染,明显高于观察组11例(32.35%)。结论:在高压氧治疗重度颅脑损伤患者基础上,醒脑静注射液可提高患者神经功能恢复程度,并减少感染的发生。
[Abstract]:Objective: to observe the effect of Xingnaojing injection combined with hyperbaric oxygen on the recovery of nerve function in patients with severe craniocerebral injury. From October 2014 to September 2016, 68 cases of severe craniocerebral injury were treated in our hospital. All patients were treated with hyperbaric oxygen on the basis of routine therapy. 34 cases were treated with Xingnaojing injection on the basis of above treatment. The recovery of nerve function was observed in two groups. Results: one month after treatment, serum ET-1 was observed in the observation group. The levels of S100B and NPY were 50.58 卤8.79ng / L 0.41 卤0.10 渭 g / L respectively 74.5 卤11.4ng / L). These results were significantly lower than those in the control group (63.82 卤9.94 ng / L, 0.60 卤0.15 渭 g / L, 93.7 卤12.0 ng / L). After 3 months of treatment, MMSE was observed in the observation group. The scores of NIHSS and memory quotient were 27.26 卤2.19, 15.89 卤1.49 and 96.81 卤4.15, respectively. It was significantly better than the control group (23.85 卤2.05, 20.14 卤1.53, 85.99 卤3.96). After 3 months of treatment, 2 patients in the control group died. There was no death in the observation group, and the ratio of good prognosis in the observation group was 50.00%. It was significantly higher than that in the control group (26.47 vs 26.47) the patients in the control group had 20 cases of lung infection during the treatment period. Conclusion: on the basis of hyperbaric oxygen treatment for patients with severe craniocerebral injury, Xingnaojing injection can improve the degree of recovery of nerve function and reduce the incidence of infection in patients with severe craniocerebral injury.
【作者单位】：南充市高坪区人民医院;川北医学院附院;
【分类号】：R651.15
【正文快照】： 重症颅脑损伤是颅脑损伤分级最高的一种,多数患者脑组织存在严重损伤,部分患者昏迷时间可达24小时以上,预后不良。颅脑损伤后前期可能仅部分脑实质受损,但随着时间进展,患者可继发多种脑实质损害,以缺血缺氧或血肿压迫等为主的继发损害将进一步加重患者病情[1]。目前尚无针对

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