乳腺导管内增生性病变中RGS2的表达及意义

发布时间：2018-02-05 05:41

  本文关键词： RGS 导管内增生性病变 免疫组化 乳腺　出处：《基因组学与应用生物学》2017年05期 　论文类型：期刊论文

【摘要】：G蛋白调节因子2(G protein regulating factors2,RGS2)表达水平的变化与多种肿瘤的发生、发展有密切关系。为了解RGS2蛋白表达水平与乳腺导管内增生性病变(intraductal proliferative lesions,IDPLs)的关系。应用免疫组化对RGS2,CK5/6进行染色,观察其在98例IDPLs(15例普通型导管增生,11例非典型导管增生,72例导管原位癌)和正常乳腺组织的表达情况。结果显示,在普通型导管增生中RGS2的表达水平分布不一致,而在其余各型的IDPLs中RGS2蛋白的阳性表达呈均匀性分布;CK5/6蛋白的阳性表达只存在于普通型导管增生中,而其余各型IDPLs均不表达;在IDPLs中RGS2的表达水平与CK5/6的表达水平呈负相关性(r=-0.995,p=0.000);随着IDPLs的级别增高,RGS2的表达逐渐丢失。结果表明,RGS2与CK5/6的联合应用可用于对IDPLs的鉴别诊断;RGS2可能作为检测IDPLs生物学行为和判断IDPLs患者预后的一项重要指标。
[Abstract]:The expression of G protein regulatory factor 2G protein regulating factors2 (RGS2) and the occurrence of many kinds of tumors. In order to understand the expression level of RGS2 protein and intraductal proliferative lesions in breast intraductal hyperplasia. Immunohistochemical staining of RGS2CK-5 / 6 was performed in 98 cases of IDPLs(15 with normal ductal hyperplasia and 11 cases with atypical ductal hyperplasia. Expression of RGS2 in 72 cases of ductal carcinoma in situ) and normal breast tissues. The results showed that the expression level of RGS2 was not consistent in normal ductal hyperplasia. The positive expression of RGS2 protein was homogeneously distributed in other types of IDPLs. The positive expression of CK5/6 protein was found only in the normal ductal hyperplasia, while none of the other types of IDPLs was expressed. There was a negative correlation between the expression of RGS2 and the expression of CK5/6 in IDPLs. The expression of RGS2 was gradually lost with the increase of IDPLs grade. The results showed that the combination of RGS2 and CK5/6 could be used in differential diagnosis of IDPLs. RGS2 may be an important index to detect the biological behavior of IDPLs and to judge the prognosis of IDPLs patients.
【作者单位】： 重庆医科大学基础医学院病理学教研室;
【基金】：重庆市卫生局重点项目(2012-1-79)资助
【分类号】：R655.8;R737.9
【正文快照】： *通讯作者,420306100@qq.comExpression and Significances of RGS2 in Intraductal Proliferative Lesionsof the BreastWang Chenglong Ye Qian Cao Youde*Department of Pathology,College of Basic Medical Sciences,Chongqingn Medical University,Chongqing,400016*Corr，

本文编号：1492282