膝骨关节炎严重程度与抵抗素水平的相关性

发布时间：2018-02-06 04:26

  本文关键词： 骨关节炎 抵抗素 滑液 生物学标记 组织工程 组织构建 骨组织工程 关节滑液 生物标记物　出处：《中国组织工程研究》2017年16期 　论文类型：期刊论文

【摘要】：背景:研究显示抵抗素表达水平与骨关节炎的发病机制密切相关。目的:旨在探讨膝骨关节炎患者的血清和关节液中抵抗素水平与膝关节病变程度的相关性。方法:选取74例膝骨关节炎患者和79例健康对照者,通过关节镜进行软骨损伤程度评分;WOMAC评分来评估患者的症状严重程度;X射线K-L分级系统评估膝关节影像学分级;ELISA检测血清和关节液中抵抗素及Ⅱ型胶原基端端肽水平。结果与结论:(1)关节液中抵抗素水平与膝放射学病变程度X射线K-L分级呈正相关,与WOMAC评分中疼痛、肢体功能及总评分成正相关,与WOMAC僵硬评分无显著的相关性;(2)骨关节炎组血清抵抗素水平与WOMAC总分、各分项评分及X射线K-L分级评分差异均无显著的相关性;(3)多元回归分析在去除混合因素后,显示关节液中抵抗素水平与WOMAC评分差异有显著性意义,关节液中抵抗素水平与Noyes评分及CTX-II水平成正相关;(4)结果说明,关节液中抵抗素水平在反映膝骨关节炎患者的病变严重程度及关节软骨退变程度上可能作为一个潜在的生物标志物。
[Abstract]:Background: studies have shown that the expression of resistin is closely related to the pathogenesis of osteoarthritis. Objective: to investigate the correlation between serum and fluid resistin levels and the degree of knee joint disease in patients with knee osteoarthritis. Methods: 74 patients with knee osteoarthritis and 79 healthy controls were selected. The degree of cartilage injury was evaluated by arthroscopy. WOMAC score was used to evaluate the severity of symptoms. X-ray K-L grading system was used to evaluate the imaging grade of knee joint. The levels of resistin and type 鈪，

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