CD64指数在特重度烧伤脓毒症患者预后评估中的价值

发布时间：2018-02-11 02:14

本文关键词： 脓毒症特重度烧伤 CD指数　出处：《山东医药》2017年09期 　论文类型：期刊论文

【摘要】：目的探讨CD64指数在特重度烧伤脓毒症患者预后评估中的价值。方法选取烧伤脓毒症住院患者32例,按结局分为死亡组(18例)和生存组(14例)。患者入院后采用直接免疫荧光法测定CD64指数;采用比浊仪测定CRP;血液分析仪检测外周血白细胞计数(WBC)和中性粒细胞比率(N)。在抗感染治疗过程中持续检测上述各指标。用ROC曲线分析患者年龄和入院第28天CD64指数对烧伤脓毒症患者预后的判断效果及其灵敏度和特异度。结果两组患者确诊脓毒症时各项指标比较差异均无统计学意义。生存组患者入院后第1、7、14天CD64指数上升,在第14天达到最高水平,然后逐渐下降;而死亡组患者CD64指数从第1天~第35天逐渐上升。在第28天和第35天两组CD64指数比较有统计学差异(P0.01)。年龄对烧伤脓毒症预后判断的最佳界值为33.5岁,灵敏度和特异度分别为0.933和0.778。入院第28天CD64指数对烧伤脓毒症患者预后判断的最佳界值为0.385,灵敏度和特异度分别为0.933和0.889。结论 CD64指数能及时评估特重度烧伤脓毒症患者病情与预后情况,对尽早实施临床干预和治疗有重要指导意义。
[Abstract]:Objective to evaluate the prognostic value of CD64 index in patients with severe burn sepsis. Methods 32 patients with burn sepsis were selected. The patients were divided into death group (n = 18) and survival group (n = 14) according to the outcome. The CD64 index was measured by direct immunofluorescence assay after admission. CRP was measured by turbidimeter, WBC count and neutrophil ratio by blood analyzer. The above indexes were continuously detected during anti-infection therapy. The age of patients and the number of CD64 fingers on the 28th day of admission were analyzed by ROC curve. Results there was no significant difference in the indexes between the two groups in the diagnosis of sepsis. The CD64 index of the patients in the survival group increased 714 days after admission. Reached the highest level on the 14th day, then gradually decreased; In the death group, the CD64 index increased gradually from day 1 to day 35. There was a significant difference in CD64 index between the two groups on the 28th and the 35th day. The best threshold of age for the prognosis of burn sepsis was 33.5 years old. The sensitivity and specificity were 0.933 and 0.778, respectively. The best value of CD64 index for the prognosis of burn sepsis patients was 0.385 on the 28th day after admission, and the sensitivity and specificity were 0.933 and 0.889 respectively. Conclusion the CD64 index can be used to evaluate the severe burn pus in time. The condition and prognosis of toxic patients, It has important guiding significance for clinical intervention and treatment as soon as possible.
【作者单位】：苏州市立医院;
【分类号】：R644;R459.7

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