9例成人横纹肌肉瘤的临床病理学分析

发布时间：2018-02-12 18:38

本文关键词： 横纹肌肉瘤成人临床病理学免疫组织化学诊断预后　出处：《上海交通大学学报(医学版)》2017年07期 　论文类型：期刊论文

【摘要】：目的·探讨成人横纹肌肉瘤(RMS)的临床病理特点及预后。方法·回顾性分析9例RMS患者临床和病理资料,及免疫组织化学检测结果。结果·该组患者平均年龄(46.89±20.09)岁,其中男性6例,女性3例。肿瘤分布范围广。组织学亚型包括胚胎性RMS 6例,腺泡状RMS、多形性RMS和梭形细胞RMS各1例。免疫组织化学检测结果显示,横纹肌标记阳性例数分别为肌细胞生成蛋白阳性6例、肌调节蛋白阳性4例、结蛋白阳性8例。7例随访中无瘤生存仅2例,带瘤生存(均为术后出现复发或转移)2例,死于肿瘤3例。结论·该组成人RMS病例中以胚胎性RMS最常见,免疫组织化学检测有助于RMS的诊断。
[Abstract]:Objective: to investigate the clinicopathological characteristics and prognosis of adult rhabdomyosarcoma. Methods: the clinical and pathological data of 9 patients with RMS and the results of immunohistochemical examination were retrospectively analyzed. Among them, 6 cases were male and 3 cases were female. There were 6 cases of embryonal RMS, 1 case of acinar RMS, 1 case of pleomorphic RMS and 1 case of fusiform cell RMS. The histological subtypes included 6 cases of embryonic RMS, 1 case of pleomorphic RMS and 1 case of fusiform cell RMS. The positive cases of rhabdomyogenic protein in 6 cases, myomodulin positive in 4 cases, desmin positive in 8 cases, tumor-free survival in 7 cases, tumor-free survival in 2 cases (both recurrence or metastasis occurred in 2 cases). Conclusion: embryonal RMS is the most common RMS in this group. Immunohistochemical examination is helpful for the diagnosis of RMS.
【作者单位】：上海交通大学医学院附属仁济医院病理科;上海交通大学医学院附属仁济医院消化科;
【分类号】：R738.7

【参考文献】