阿托伐他汀钙片治疗非创伤性硬膜下血肿的临床研究

发布时间：2018-02-17 04:45

  本文关键词： 阿托伐他汀钙片 非创伤性硬膜下血肿 安全性　出处：《中国临床药理学杂志》2017年18期 　论文类型：期刊论文

【摘要】：目的观察阿托伐他汀钙片治疗非创伤性硬膜下血肿的临床疗效及安全性。方法将52例非创伤性硬膜下血肿患者随机分为对照组26例和试验组26例。对照组予以钻孔引流术治疗,封闭骨孔并进行闭式引流2~3 d;试验组在对照组治疗的基础上,予以阿托伐他汀钙片20 mg,qd,口服,连续用药28 d。比较2组患者的临床疗效、血清中超氧化物歧化酶(SOD)、丙二醛(MDA)水平、复发率,以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为84.62%(22/26例)和57.69%(15/26例),差异有统计学意义(P0.05)。治疗后,对照组和试验组的SOD分别为(115.29±13.34)和(128.39±14.29)U·m L~(-1),MDA分别为(19.83±2.43)和(15.40±1.67)nmol·m L~(-1),复发率分别为26.92%(7/26例)和0(0/26例),差异均有统计学意义(均P0.05)。试验组发生的药物不良反应有血肿量增加和感染,对照组发生的药物不良反应有颅内气肿、血肿量增加、感染、肝功能异常、脑损伤,试验组和对照组的药物不良反应发生率分别为7.69%和34.62%,差异有统计学意义(P0.05)。结论阿托伐他汀钙片治疗非创伤性硬膜下血肿的临床疗效显著,且药物不良反应发生率和复发率均较低。
[Abstract]:Objective to observe the clinical efficacy and safety of Atto vastatin calcium tablets in the treatment of non-traumatic subdural hematoma. Methods 52 patients with non-traumatic subdural hematoma were randomly divided into control group (n = 26) and experimental group (n = 26). On the basis of treatment in the control group, the experimental group was given the calcium tablet of Atto vastatin 20 mg / g QD orally for 28 days. The clinical efficacy, serum levels of superoxide dismutase (SOD) and malondialdehyde (MDA) were compared between the two groups. Results after treatment, the total effective rates of the treatment group and the control group were 84.62 / 22 / 26 and 57.6969 / 15 / 26, respectively. The difference was statistically significant (P 0.05). The SOD of the control group and the trial group were 115.29 卤13.34 and 128.39 卤14.29 U 路mL ~ (-1), respectively (19.83 卤2.43) and 15.40 卤1.67 nmol 路mL ~ (-1), respectively. The recurrence rate was 26.92i / 726 cases, and there were significant differences between the two groups. Adverse drug reactions in the control group included intracranial emphysema, increased hematoma, infection, abnormal liver function, brain injury, The incidence of adverse drug reactions in the trial group and the control group were 7.69% and 34.62, respectively. The difference was statistically significant (P 0.05). Conclusion the clinical efficacy of Atto vastatin calcium tablets in the treatment of non-traumatic subdural hematoma is significant. The incidence and recurrence rate of adverse drug reactions were lower.
【作者单位】： 遵义医学院第三附属医院神经外科;
【基金】：贵州省科技计划基金资助项目[SY(2012)3118]
【分类号】：R651.1
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