右美托咪定复合地佐辛对瑞芬太尼所致术后痛觉过敏的影响

发布时间：2018-03-01 07:26

本文关键词： 右美托咪定地佐辛痛觉过敏血流动力学视觉模拟评分　出处：《广东医学》2017年S1期 　论文类型：期刊论文

【摘要】：目的右美托咪定复合地佐辛对瑞芬太尼所致术后痛觉过敏的影响。方法选择接受择期腹腔镜胆囊切除患者90例,患者全部使用气管内全身麻醉。完成插管后,将上述患者随机分为右美托咪定-地佐辛组(DZ组)、右美托咪定组(D组)和对照组(C组),每组30例。DZ组患者以右美托咪定0.3μg/(kg·h)持续静脉泵注30 min并在手术结束前20 min静脉给予地佐辛0.1 mg/kg;D组患者以右美托咪定0.3μg/(kg·h)持续静脉泵注30 min;C组患者予等量生理盐水持续静脉泵注30 min。所有患者于术后1、3、6、12、24 h测量视觉模拟评分(VAS);24 h累计按压患者自控镇痛(PCA)按钮次数;第1次按压PCA按钮时间和解救镇痛药物给予剂量;镇痛过程中患者心率低于50次/min或无创动脉平均血压低于术前80%的例次。结果术后各时点VAS评分C组D组DZ组;24 h累计按压PCA按钮次数和解救镇痛药物给予剂量C组D组DZ组;第1次按压PCA按钮时间C组D组DZ组。3组患者镇痛过程中心动过缓和低血压发生情况差异无统计学意义。结论 0.3μg/(kg·h)右美托咪定与地佐辛配合使用,可以有效缓解瑞芬太尼引起的痛觉过敏,对血流动力学影响小。
[Abstract]:Objective effects of dexmedetomidine combined with dezocine on postoperative hyperalgesia induced by Reventa Ni. Methods patients undergoing laparoscopic cholecystectomy in 90 cases, all patients using intratracheal anesthesia. After intubation, the patients were randomly divided into dexmedetomidine, dezocine group (group DZ), dexmedetomidine group (D group) and control group (C group), each group of 30 cases of.DZ patients with dexmedetomidine 0.3 g/ (kg - H) continuous intravenous infusion of 30 min and 20 min before the end of surgery intravenous dezocine 0.1 mg/kg; group D patients with dexmedetomidine (0.3 g/ kg - H) continuous intravenous infusion of 30 min; group C received saline continuous intravenous infusion of 30 min. of all patients in the postoperative 1,3,6,12,24 h measurement of visual analogue scale (VAS); 24 h cumulative patient-controlled analgesia (PCA) press the button first times; press the PCA button to save time and analgesic drugs given dose; analgesia In patients with a heart rate of less than 50 /min or noninvasive arterial blood pressure less than the average 80% cases before operation. Results after operation, the VAS scores of C group D group DZ group; 24 h cumulative number and press the PCA button to rescue analgesic doses of C group D group DZ group; bradycardia and hypotension no difference. Statistical significance first times to press the PCA button time C group D group DZ group.3 group analgesia. Conclusion 0.3 g/ (kg - H) of dexmedetomidine combined with dezocine can effectively relieve remifentanil induced hyperalgesia and hemodynamics.

【作者单位】：上海市同仁医院麻醉科;
【基金】：长宁区卫生和计划生育委员会科研课题(编号:20154Y006)
【分类号】：R614

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