髌下脂肪垫体积与膝骨性关节炎相关性研究

发布时间：2018-03-02 13:08

本文选题：髌下脂肪垫　切入点：膝关节骨关节炎　出处：《中国矫形外科杂志》2017年09期 　论文类型：期刊论文

【摘要】：[目的]探讨髌下脂肪垫(infrapatellar fat pad,IPFP)体积与膝关节骨关节炎(Keen Osteoarthritis,KOA)的关系。[方法]对体检职工进行横断面研究,排除膝关节外伤、感染、免疫性疾病后,共纳入114位受试者(114膝)行膝关节MRI扫描。利用mimics16.0处理T1加权图像测定IPFP体积;利用质子密度加权图像对膝关节软骨缺损、骨赘评分;利用WOMAC量表评估膝关节疼痛。分析IPFP体积与软骨缺损、骨赘、疼痛的相关性;并进一步把受试者分为OA组和对照组,比较组间IPFP体积差异性。[结果]多因素分析显示IPFP体积与股骨外侧、胫骨内侧、胫骨外侧、全膝关节骨赘及睡眠、平地行走时膝关节疼痛呈显著负相关;OA组IPFP体积小于非OA组,但差异无统计学意义。[结论]IPFP体积减少与膝关节退变有相关性,但KOA患者IPFP体积较健康人减少并不显著,提示力学作用可能不是IPFP影响KOA的主要途径。
[Abstract]:[objective] to investigate the relationship between the volume of infrapatellar fat fat and knee osteoarthritis (KOAA). The volume of IPFP was measured by mimics16.0 on T1 weighted images, and the cartilage defects and osteophyte scores were evaluated by proton density weighted images. The WOMAC scale was used to evaluate knee joint pain. The correlation between IPFP volume and cartilage defect, osteophyte and pain was analyzed, and the subjects were further divided into OA group and control group. [results] Multivariate analysis showed that the volume of IPFP was negatively correlated with the lateral femur, the medial tibia, the lateral tibia, the total knee osteophyte and sleep, and the knee joint pain when walking flat. The volume of IPFP in OA group was lower than that in non-OA group. But the difference was not statistically significant. [conclusion] there is a correlation between the volume reduction of IPFP and degeneration of knee joint, but the decrease of IPFP volume in KOA patients is not significant compared with that in healthy people, suggesting that the mechanical effect may not be the main way of IPFP affecting KOA.
【作者单位】：中南大学湘雅三医院骨科;天津医科大学总医院消化科;
【基金】：国家自然科学基金项目(编号:8157090738)
【分类号】：R684.3

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