国外局部外用药控制膝骨关节炎疼痛的临床研究进展

发布时间：2018-03-02 18:45

本文选题：膝骨关节炎　切入点：疼痛　出处：《中国疼痛医学杂志》2016年02期 　论文类型：期刊论文

【摘要】：膝关节骨性关节炎(knee osteoarthritis,KOA)疼痛非常复杂,口服药物不良反应多,不利长期应用。本文介绍局部外用药用以控制KOA源性疼痛的现状。检索Pub Med、EMBASE、Cochrane临床对照试验库、Cochrane图书馆,检索时间均从1990年1月至2014年6月。根据局部外用药物用以治疗KOA的临床试验相关报道,共纳入16种药物,其中欧盟流通非甾体抗炎药物7种:酮洛芬、双氯芬酸、氟比洛芬酯、吡罗昔康透皮贴剂、布洛芬、吡罗昔康和尼氟灭酸凝胶;酰胺类局麻药物1种:利多卡因;阿片类药物2种:芬太尼和曲马多;草本药提取物4种:辣椒素、山金车、橄榄油和紫草科植物。外治法药物控制KOA疼痛,首推双氯芬酸、酮洛芬、吡罗昔康,起效快、安全性高。草本类药物橄榄油、山金车、辣椒素、紫草科植物萃取物可供选择。局部药物外治是KOA镇痛的重要选择,国外此方面研究方兴未艾,国内需及时跟进。
[Abstract]:Knee osteoarthritis osteoarthritis KOAA is very complicated, oral adverse drug reactions are many, unfavorable long-term application. This paper introduces the current situation of topical administration to control pain caused by KOA. The retrieval time was from January 1990 to June 2014. According to the related reports of clinical trials of topical use of drugs for the treatment of KOA, a total of 16 kinds of drugs were included, including 7 non-steroidal anti-inflammatory drugs in circulation in the European Union: ketoprofen, diclofenac, diclofenac, ketoprofen and diclofenac. Flurbiprofen Ester, Piroxicam Transdermal Patch, Ibuprofen, Piroxicam and Nifluronide Gel; Amide Local Anesthesia 1: lidocaine; opioids 2: fentanyl and Tramadol; herbaceous extract 4 kinds: capsaicin, capsaicin, Herbal medicine for the control of KOA pain, first of all diclofenac, ketoprofen, Piroxicam, quick onset, high safety. Herbaceous drugs olive oil, Yamamoto, capsaicin, Local drug treatment is an important choice for KOA analgesia. The research on this aspect is in the ascendant abroad, and it is necessary to follow up in China.
【作者单位】：南京中医药大学第一临床医学院;南京中医药大学附属医院骨伤科;
【基金】：国家自然科学基金(81573993) 江苏省基础研究计划(自然科学基金BK20151589) 江苏省中医院周福贻全国名老中医工作室
【分类号】：R684.3

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