激素性股骨头缺血性坏死发病机制中的细胞自噬

发布时间：2018-03-02 21:38

本文选题：股骨头坏死　切入点：自噬　出处：《中国组织工程研究》2017年08期 　论文类型：期刊论文

【摘要】：背景:临床研究表明骨细胞自噬参与了激素性股骨头坏死的病理过程,并与细胞凋亡关系密切。目的:通过对细胞自噬与细胞凋亡及骨细胞的相互作用关系,总结细胞自噬在激素性股骨头缺血坏死发病机制中的研究进展。方法:由第一作者应用计算机检索应用计算机检索PubMed数据库,embase数据库,CNKI数据库中从1996年10月到2016年10月出版的文献,检索词分别为"steroid;necrosis of the femoral head;cell apoptosis;cell autophagy;osteocyte"和"糖皮质激素;股骨头坏死;骨细胞;细胞凋亡;细胞自噬"。选择激素性股骨头坏死与细胞自噬的文章,排除重复及较陈旧的文献及Meta分析。结果与结论:哺乳动物雷帕霉素靶蛋白、Beclin-1、微管相关蛋白1轻链3及骨形成蛋白、叉头框蛋白和转录基因家族和转录因子4等与细胞自噬关系密切;细胞自噬与骨细胞的相互作用与激素剂量密切相关,低剂量激素作用下,细胞自噬表现为保护作用,而随着剂量的增多,出现了大量细胞凋亡现象,同时也出现骨量减少,骨易碎性增加的现象,而细胞自噬与骨量维持、细胞凋亡的具体关系现在仍存在争论,需要进一步通过合理的实验设计去研究。
[Abstract]:Background: clinical studies have shown that osteocyte autophagy is involved in the pathological process of steroid-induced femoral head necrosis and is closely related to apoptosis. Objective: to study the relationship between autophagy and apoptosis and the interaction between osteocyte and autophagy. To summarize the research progress of autophagy in the pathogenesis of steroid-induced avascular necrosis of the femoral head. Methods: from October 1996 to 2016, the authors used the computer to search the PubMed database. Published in October, The key words are "steroidnecrosis of the femoral head cell apoptosis" and "glucocorticoid; femoral head necrosis; osteocyte; apoptosis; autophagy". Results and conclusions: the mammalian rapamycin target protein, Beclin-1, microtubule-associated protein 1, light chain 3 and bone morphogenetic protein were excluded. The interaction between cellular autophagy and osteocyte is closely related to the dose of hormone, and the effect of low dose hormone on cell autophagy is a protective effect, while the family of forkhead protein and transcription gene and transcription factor 4 are closely related to autophagy, and the interaction between cell autophagy and bone cell is closely related to the dose of hormone. However, with the increase of dosage, a large number of apoptotic cells appeared, and at the same time, there was a decrease in bone mass and an increase in bone fragility. The specific relationship between autophagy and bone mass maintenance, cell apoptosis is still controversial. Further research is needed through reasonable experimental design.
【作者单位】：内蒙古医科大学研究生院;内蒙古医科大学第二附属医院;
【基金】：国家自然科学基金项目(81360273,81460331,81560349)~~
【分类号】：R681.8

【相似文献】